Description

Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2-[(methoxyacetyl)amino]-N-(2-methyl-1-oxopropyl)-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI) is a highly specialized, protected nucleoside phosphoramidite monomer, a critical building block in the automated synthesis of oligonucleotides. This compound is engineered for high coupling efficiency and stability during solid-phase synthesis, ensuring the production of high-purity DNA and RNA sequences. It is an essential raw material for pharmaceutical R&D, diagnostic assay development, and academic research in genomics and molecular biology.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated solid-phase synthesis of modified DNA and RNA strands.
• Therapeutic Development: For the research and production of antisense oligonucleotides (ASOs), siRNA, and aptamers for targeted therapies.
• Diagnostic Probes: Manufacture of labeled probes and primers used in PCR, sequencing, and microarray technologies.
• Biochemical Research: Tool compound for studying nucleic acid structure, function, and protein-nucleic acid interactions.
• Synthetic Biology: Construction of artificial genes and genetic circuits with specific, engineered functionalities.
• High-Value Fine Chemical: Serves as an intermediate in the multi-step synthesis of complex nucleoside analogs and pharmaceutical candidates.

Basic Information

Product Name	Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2-[(methoxyacetyl)amino]-N-(2-methyl-1-oxopropyl)-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)
CAS No.	872548-56-6
Molecular Formula	C58H78N7O10PSi
Molecular Weight	~1101.33 g/mol
Synonyms	5'-O-DMT-2'-O-TOM-2-N-MOC-Adenosine-3'-CEA Phosphoramidite; 2'-O-[(Triisopropylsilyl)oxy]methyl-5'-O-(4,4'-dimethoxytrityl)-N2-(methoxyacetyl)adenosine-3'-[2-cyanoethyl-N,N-diisopropyl]phosphoramidite; 2'-O-TOM-Adenosine(N2-MOC) Phosphoramidite; 5'-DMT-2'-O-TOM-A(N2-MOC)-CE Phosphoramidite; 2'-O-TOM Protected Adenosine Phosphoramidite; TOM-A(MOC)-Phosphoramidite; Adenosine, N2-MOC, 2'-O-TOM, 5'-O-DMT, 3'-[2-cyanoethyl (N,N-diisopropyl)]phosphoramidite
EINECS	Contact for details

Quality Control

Every batch of this high-purity phosphoramidite is subjected to rigorous analytical testing, including HPLC, 31P NMR, and 1H NMR, to ensure identity, purity, and suitability for oligonucleotide synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality management system supports production for research and GMP-grade applications, ensuring traceability and compliance with global standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This compound is hygroscopic (moisture-sensitive) and easily oxidized. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (31P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Solubility	Clear, colorless solution in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.