Description

Netropsin is a naturally occurring, non-intercalating, minor groove-binding oligopeptide antibiotic with significant biological activity. Its unique binding specificity for AT-rich sequences of double-stranded DNA makes it a critical tool in molecular biology and biochemical research. This compound is primarily utilized by researchers in pharmaceutical development, life sciences, and academic institutions for studying nucleic acid structure, protein-DNA interactions, and as a potential lead compound for therapeutic agents.

Application

• Molecular Biology Research: Used as a specific probe for studying the structure and function of DNA, particularly in footprinting assays to map protein-binding sites.
• Biochemical Studies: Serves as a model compound for investigating minor groove binding interactions and the thermodynamics of ligand-DNA recognition.
• Pharmaceutical R&D: Investigated for its antiviral and antitumor properties, acting as a template for designing novel chemotherapeutic agents that target genetic material.
• Academic Research: Employed in laboratories to understand gene regulation and as a tool to inhibit specific DNA-protein interactions in vitro.
• Diagnostic Development: Potential use in developing assays that detect specific DNA sequences based on its binding affinity.

Basic Information

Product Name	Netropsin
CAS No.	1438-30-8
Molecular Formula	C₁₈H₂₆N₁₀O₄
Molecular Weight	446.47 g/mol
Synonyms	Netropsin; Congocidine; Sinanomycin; Antibiotic 1438-30-8; NSC 57153; 2-[[5-[[(4-Amidino-1-methylpyrrol-2-yl)carbonyl]amino]-1-methylpyrrol-2-yl]carbonyl]amino]ethanimidamide; 1-Methyl-N-[1-methyl-5-[[(4-[(aminoiminomethyl)amino]-1-methyl-1H-pyrrol-2-yl)carbonyl]amino]-1H-pyrrol-2-yl]-1H-pyrrole-4-carboximidamide
EINECS	Contact for details

Quality Control

Our Netropsin is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals to guarantee reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.