Description

Phleomycin E is a potent glycopeptide antibiotic belonging to the bleomycin family, known for its ability to cleave DNA in the presence of oxygen and metal ions. Its primary commercial value lies in its application as a selective agent in molecular biology and genetic research, particularly for the selection of genetically modified organisms. This product is essential for researchers and manufacturers in the biotechnology, pharmaceutical development, and life science research sectors who require high-purity biochemical tools.

Application

• Molecular Biology Research: Used as a selective agent in bacterial and yeast genetics for the selection of transformed cells containing resistance markers.
• Antibiotic Mode-of-Study: Serves as a key biochemical tool in studies investigating the mechanism of action of DNA-cleaving antibiotics.
• Cell Culture & Microbiology: Employed in selective media for maintaining plasmid stability in recombinant bacterial strains.
• Biochemical Reagent: Acts as a critical component in assays designed to study DNA damage and repair pathways.
• Pharmaceutical Screening: Utilized in discovery research for evaluating novel antimicrobial or anticancer compounds.

Basic Information

Product Name	Phleomycin E
CAS No.	11031-13-3
Molecular Formula	C₅₅H₈₄N₁₇O₂₁S₂
Molecular Weight	Approx. 1400 g/mol
Synonyms	Phleomycin E; Phleomycin E complex; Bleomycin A2; Bleomycin A2 Hydrochloride; NSC-56364; Z-11031-13-3; Antibiotic Z-11031-13-3; N-[3-[[[2-[[[5-[[(2S)-2,3-Diamino-3-oxopropyl]amino]-1H-pyrimidin-2-yl]carbonyl]amino]ethyl]amino]carbonyl]-2-hydroxypropyl]-β-alaninamide (component of)
EINECS	Contact for details

Quality Control

Our Phleomycin E is produced under strict quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods and purity assessment by HPLC. A Certificate of Analysis (COA) detailing the specific results for potency, purity, and related substances is provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to reach room temperature before opening to prevent moisture condensation. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Potency (Microbiological)	≥ 90% of labeled activity
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Biological Activity	Confirmed by selective growth inhibition assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.