Description

Deoxyguanylyl-(3'-5')-Guanosine is a defined dinucleotide, specifically a deoxyguanosine dimer linked by a 3'-5' phosphodiester bond. This compound serves as a critical building block and reference standard in nucleic acid research and therapeutic development. It is essential for scientists and manufacturers in the fields of oligonucleotide synthesis, molecular biology, and pharmaceutical R&D who require high-purity, structurally defined nucleotide components.

Application

• Oligonucleotide Synthesis: Used as a controlled dimer unit or intermediate in the solid-phase and solution-phase synthesis of DNA strands.
• Biochemical Research: Serves as a substrate or model compound for studying enzyme kinetics, particularly for nucleases, polymerases, and phosphorylases.
• Pharmaceutical Reference Standard: Employed as a certified reference material (CRM) for quality control and analytical method development in antisense oligonucleotide and mRNA therapeutic production.
• Diagnostic Probe Development: Acts as a core component in the design and calibration of hybridization probes and primers for genetic testing.
• Enzyme Mechanism Studies: Provides a specific structural motif for investigating the binding and catalytic mechanisms of nucleic acid-interacting proteins.

Basic Information

Product Name	Deoxyguanylyl-(3'-5')-Guanosine
CAS No.	15180-30-0
Molecular Formula	C20H25N10O11P
Molecular Weight	612.45 g/mol
Synonyms	d(GpG); dGpdG; Deoxyguanylyl-(3'→5')-deoxyguanosine; Guanylyl-(3'-5')-2'-deoxyguanosine; 2'-Deoxyguanylyl-(3'-5')-2'-deoxyguanosine; pdGpdG; Dinucleotide d(GpG); G(p)G (2'-deoxy)
EINECS	Contact for details

Quality Control

Our Deoxyguanylyl-(3'-5')-Guanosine is produced under stringent conditions to ensure high chemical purity and batch-to-batch consistency, suitable for demanding research and development applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.