Description

3-Methyl-3H-diazirine-3-methanol is a versatile heterocyclic compound featuring a highly reactive diazirine ring. This compound matters as a critical photoaffinity labeling agent and crosslinking reagent in advanced biochemical research. It is primarily needed by researchers in pharmaceutical development, proteomics, and materials science for studying molecular interactions and creating novel polymer networks.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalently tagging biomolecules (proteins, nucleic acids) upon UV light activation to map binding sites and study biological pathways.
• Bioconjugation & Crosslinking: Used to create stable covalent bonds between biomolecules or between biomolecules and surfaces for biosensor development and diagnostic assays.
• Polymer Chemistry: Serves as a photoinitiator or crosslinker monomer for synthesizing specialized polymers and hydrogels with light-responsive properties.
• Chemical Biology Probes: Incorporated into probe molecules to capture transient or weak protein-ligand interactions for drug discovery.
• Surface Modification: Enables the functionalization of materials (e.g., chips, nanoparticles) with bioactive ligands for cell culture and tissue engineering applications.
• Organic Synthesis Intermediate: Acts as a building block for synthesizing more complex diazirine-containing compounds and heterocycles.

Basic Information

Item	Details
Product Name	3-Methyl-3H-Diazirine-3-Methanol
CAS No.	14757-55-2
Molecular Formula	C4H8N2O
Molecular Weight	100.12 g/mol
Synonyms	3-(Hydroxymethyl)-3-methyldiazirine; 3-Methyl-3-(hydroxymethyl)diazirine; Diaziridine-3-methanol, 3-methyl-; 3-Methyl-3H-diazirine-3-methanol; 3-Methyldiaziridine-3-methanol; Photoaffinity labeling reagent; Diazirine crosslinker
EINECS	Contact for details

Quality Control

Our 3-Methyl-3H-diazirine-3-methanol is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) to minimize degradation and volatility. Keep away from heat, sparks, and open flames. Due to its light-sensitive and highly volatile nature, allow the container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.