Description

(1aS,8S,8aR,8bS)-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-6-(1H-pyrazole-3-ylamino)azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione is a complex, high-purity synthetic intermediate of significant interest in advanced pharmaceutical research and development. This compound matters because its intricate azirino-pyrrolo-indole core structure serves as a critical building block for the synthesis of novel, potent therapeutic agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries, particularly those focused on oncology and targeted therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs) with complex heterocyclic architectures.
• Oncology Research: Used in the development of potential anti-cancer compounds, leveraging its biologically active scaffold for targeted molecule design.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial-scale manufacturing of specialized pharmaceuticals.
• Bioconjugation & Prodrug Development: The functional groups present allow for potential use in creating targeted drug delivery systems or prodrug formulations.
• Reference Standard: Provides a high-purity material for analytical method development, validation, and quality control in API production.

Basic Information

Product Name	(1aS,8S,8aR,8bS)-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-6-(1H-pyrazole-3-ylamino)azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
CAS No.	84397-45-5
Molecular Formula	C19H22N6O6
Molecular Weight	430.42 g/mol
Synonyms	Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione derivative; UCB-745; 8-[(Aminocarbonyloxy)methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-6-(1H-pyrazol-3-ylamino)azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; 8-[(Carbamoyloxy)methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-6-(1H-pyrazol-3-ylamino)azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione; 84397-45-5; UCB745; UCB 745
EINECS	Contact for details

Quality Control

Our (1aS,8S,8aR,8bS)-8-[[(Aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-6-(1H-pyrazole-3-ylamino)azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring the material meets the exacting standards required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a dry environment. This compound is light-sensitive and easily oxidized; prolonged exposure to light, air, or moisture should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.