Description

Nogalamycin CAS NO 1404-15-5 is a potent anthracycline antibiotic isolated from *Streptomyces* species. This compound is a critical research tool valued for its unique mechanism of action, which involves intercalation into DNA and inhibition of topoisomerase II, making it a compound of significant interest in biochemical and pharmacological studies. It is primarily sought by researchers and developers in the fields of oncology research, molecular biology, and antibiotic discovery for investigating novel therapeutic pathways and resistance mechanisms.

Application

• Oncology and Cancer Research: Used as a reference standard and investigative agent in studies targeting DNA replication and topoisomerase inhibition for potential anti-cancer drug development.
• Biochemical Research: Serves as a key molecular probe for studying DNA-intercalation mechanisms, nucleic acid structure, and enzyme interactions in vitro.
• Antibiotic Mechanism Studies: Employed in microbiological research to understand the action of anthracycline antibiotics and to explore bacterial resistance patterns.
• Pharmaceutical Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.
• Academic Research & Development: A vital reagent in university and institutional labs for graduate-level research and publications in chemical biology and medicinal chemistry.

Basic Information

Product Name	Nogalamycin
CAS No.	1404-15-5
Molecular Formula	C39H49NO16
Molecular Weight	787.81 g/mol
Synonyms	Nogalamycin; Antibiotic U-15167; NSC-70845; 7-O-(6-Deoxy-α-L-mannopyranosyl)-nogalarol; (1S,2R,4S)-4-[(2R,4S,5S,6S)-4-(Dimethylamino)-5-[(2S,4S,5S,6S)-4-hydroxy-6-methyl-5-[(2R,3R,4S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-methyloxan-2-yl]oxy-1,2,5-trihydroxy-7,8,9,10-tetrahydro-7,10,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Nogalamycin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals, ensuring reliable and reproducible results for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture absorption. For long-term storage, keep the primary container in a secondary protective enclosure.

Specification

Item	Specification
Appearance	Red-orange to red-brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 1.0%
Specific Rotation	Contact for details
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.