Description

Carzinophilin is a potent aziridine-containing antitumor antibiotic isolated from *Streptomyces sahachiroi*. This compound matters for its significant biological activity, primarily functioning as a DNA alkylating agent, which makes it a valuable reference standard and research tool in oncology and biochemistry. It is needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cancer drug discovery, mechanism of action studies, and the development of novel chemotherapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in the discovery and development of novel anticancer therapies.
• Biochemical Studies: Used as a precise DNA alkylating agent in laboratory research to investigate DNA damage, repair mechanisms, and cellular apoptosis pathways.
• Academic Research: Employed in university and institutional labs for studying the structure-activity relationships (SAR) of antitumor antibiotics and their mechanisms of cytotoxicity.
• Oncology Screening: Utilized in in vitro and in vivo assays to screen for synergistic effects with other chemotherapeutic agents or to evaluate resistance mechanisms in cancer cell lines.
• Quality Control & Analytical Testing: Acts as a high-purity calibrant in analytical methods (e.g., HPLC, LC-MS) for quality assurance in pharmaceutical manufacturing and research.

Basic Information

Product Name	Carzinophilin
CAS No.	1403-29-8
Molecular Formula	C15H18N4O6
Molecular Weight	350.33 g/mol
Synonyms	Carzinophilin A; NSC-525816; Antibiotic 289; Azinomycin A; Carzinophilin A; LIA-0695; Antibiotic from *Streptomyces sahachiroi*
EINECS	Contact for details

Quality Control

Our Carzinophilin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR) and purity determination by HPLC. A detailed Certificate of Analysis (COA) containing all test results and specifications is provided with every shipment to guarantee traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.