Description

Actinomycin E2 is a potent antibiotic and antitumor agent belonging to the actinomycin family of chromopeptides. This compound is of significant interest in biochemical and pharmaceutical research due to its ability to intercalate into DNA and inhibit transcription. It serves as a critical research tool for scientists in oncology, molecular biology, and microbiology. The product is supplied as a high-purity reference standard and active pharmaceutical ingredient (API) intermediate for advanced research and development.

Application

• Oncology Research: Used as a reference standard and investigative agent in cancer research to study mechanisms of DNA intercalation and transcription inhibition.
• Biochemical Studies: Employed in molecular biology laboratories to probe nucleic acid structure and function, and to study RNA polymerase inhibition.
• Antimicrobial Research: Investigated for its potent antibacterial and antifungal properties in microbiological studies.
• Pharmaceutical Development: Serves as a key intermediate or reference compound in the development and quality control of novel chemotherapeutic agents.
• Cell Biology: Utilized in studies of apoptosis (programmed cell death) and cell cycle arrest.
• Academic Research: A vital reagent for universities and research institutes exploring the biochemistry of natural product antibiotics.

Basic Information

Product Name	Actinomycin E2
CAS No.	1402-42-2
Molecular Formula	C62H86N12O16
Molecular Weight	1279.44 g/mol
Synonyms	Actinomycin E2; Actinomycin IV; Actinomycin C2; Actinomycin D analogue; 7-Aminoactinomycin D analogue; NSC 627372; Antibiotic from Streptomyces parvulus; Chromopeptide antibiotic
EINECS	Contact for details

Quality Control

Our Actinomycin E2 is manufactured under strict quality control protocols to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC and MS, to confirm identity and potency. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Red-orange to red crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Solvent Residues (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.