Description

Actinomycin I CAS NO 1402-60-4 is a potent chromopeptide antibiotic belonging to the actinomycin family, known for its characteristic chromophore and ability to intercalate into DNA. This compound is of significant value in biochemical and pharmaceutical research due to its mechanism of action, which inhibits transcription by binding to double-stranded DNA. It is primarily required by research institutions, pharmaceutical developers, and biotechnology companies for applications in molecular biology, oncology research, and as a reference standard.

Application

• Biochemical Research: Used as a potent inhibitor of DNA-dependent RNA synthesis to study transcription mechanisms and nucleic acid interactions.
• Oncology and Cancer Research: Serves as a critical tool compound for investigating apoptosis, cell cycle arrest, and evaluating chemotherapeutic pathways in vitro.
• Antibiotic Studies: Employed in microbiological research to study the activity and resistance mechanisms of actinomycin-class antibiotics.
• Pharmaceutical Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Molecular Biology Reagent: Applied in laboratory protocols to selectively inhibit transcriptional processes in cell cultures and experimental models.

Basic Information

Product Name	Actinomycin I
CAS No.	1402-60-4
Molecular Formula	C62H86N12O16
Molecular Weight	1271.42 g/mol
Synonyms	Actinomycin C1; Actinomycin I; Actinomycin VII; Dactinomycin (related compound); Actinomycin C; Sanamycin; Lyovac; Meractinomycin; Cosmegen (brand name for Dactinomycin); Antibiotic from *Streptomyces*.
EINECS	Contact for details

Quality Control

Our Actinomycin I is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including purity assay and identity confirmation. A Certificate of Analysis (COA) detailing specific test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider conditions of 2-8°C.

Specification

Item	Specification
Appearance	Red crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.