Description

Actinomycin F0 CAS NO 1402-43-3 is a potent chromopeptide antibiotic belonging to the actinomycin family, known for its characteristic phenoxazone chromophore. This compound is of significant interest in biochemical and pharmaceutical research due to its ability to intercalate into DNA and inhibit transcription. It serves as a critical research tool for scientists in oncology, molecular biology, and microbiology, enabling studies on nucleic acid interactions and the mechanisms of antibiotic action.

Application

• Biochemical Research: Used as a specific inhibitor of DNA-dependent RNA synthesis to study transcription mechanisms and gene expression.
• Oncology Research: Employed in in vitro and in vivo studies to investigate its cytotoxic effects and mechanisms of action against various cancer cell lines.
• Antibiotic Mechanism Studies: Serves as a model compound for researching the activity and resistance mechanisms of peptide antibiotics.
• Microbiological Studies: Applied in selective media and experiments to study its effects on prokaryotic organisms.
• Reference Standard: Utilized as a high-purity analytical standard in pharmaceutical quality control and method development for HPLC and other chromatographic techniques.
• Molecular Probe Development: Acts as a foundational structure for developing novel probes targeting nucleic acids.

Basic Information

Product Name	Actinomycin F0
CAS No.	1402-43-3
Molecular Formula	C62H86N12O16
Molecular Weight	1255.42 g/mol
Synonyms	Actinomycin F0; Actinomycin V; Actinomycin C3; Dactinomycin analogue; NSC 19880; Antibiotic F0; Actinomycin F-0; Actinomycin Fo
EINECS	Contact for details

Quality Control

Our Actinomycin F0 is produced and tested under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analysis, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). For long-term storage, consider desiccation and storage under inert atmosphere.

Specification

Item	Specification
Appearance	Orange-red to red crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.