Description

1A-Acetylmitomycin C is a chemically modified derivative of the potent antitumor antibiotic mitomycin C. This compound is of significant interest in pharmaceutical research and development, particularly for the synthesis of novel prodrugs and targeted cancer therapeutics. It serves as a critical intermediate and research tool for oncology-focused biotech firms, academic research institutions, and pharmaceutical companies engaged in anticancer drug discovery.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of advanced mitomycin analogs and prodrug candidates.
• Anticancer Research: Used in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) and mechanisms of action.
• Bioconjugation Studies: Employed in the development of antibody-drug conjugates (ADCs) and other targeted delivery systems due to its modifiable acetyl group.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Development: Utilized in *in vitro* and *in vivo* models to evaluate the efficacy and toxicity profiles of new chemotherapeutic agents.

Basic Information

Product Name	1A-Acetylmitomycin C
CAS No.	1102-95-0
Molecular Formula	C₁₇H₂₁N₃O₇
Molecular Weight	379.37 g/mol
Synonyms	7-Amino-9α-methoxy-4-methyl-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione 1a-acetate; Acetylmitomycin C; 1a-Acetylmitomycin; Mitomycin C 1a-acetate; N-Acetylmitomycin C
EINECS	Contact for details

Quality Control

Our 1A-Acetylmitomycin C is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the container to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange-brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.