Description

[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxyphosphonic acid is a high-purity, chemically defined nucleotide analog of significant research and therapeutic interest. This compound serves as a critical building block and active pharmaceutical ingredient (API) intermediate in the development of novel antiviral and anticancer therapeutics. It is essential for pharmaceutical R&D laboratories, biotechnology companies, and advanced fine chemical synthesis operations focused on nucleoside-based drug discovery.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex nucleoside analog prodrugs and oligonucleotides.
• Antiviral Drug Research: Used in the development of nucleotide reverse transcriptase inhibitors (NRTIs) and other antiviral agents targeting viral polymerases.
• Oncology Research: Investigated as a component of chemotherapeutic agents designed to inhibit DNA replication in cancer cells.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies involving DNA/RNA polymerases and kinases.
• ProTide Technology: A central compound in the synthesis of ProTide prodrugs, which enhance cellular delivery and activation of nucleoside monophosphates.
• Fine Chemical Synthesis: Building block for custom oligonucleotide synthesis and the creation of labeled compounds for diagnostic assays.

Basic Information

Product Name	[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxyphosphonic acid
CAS No.	2945-57-5
Molecular Formula	C45H60N8O32P4
Molecular Weight	1449.90 g/mol
Synonyms	d4T-5'-H-Phosphonate Tetramer; Stavudine 5'-H-Phosphonate Oligomer (4-mer); 2',3'-Didehydro-2',3'-dideoxythymidine 5'-H-phosphonate tetramer; 1-[(2R,3S,5R)-3-Hydroxy-5-[[hydroxy-[([(2R,3S,5R)-5-(5-Methyl-2,4-dioxopyrimidin-1-yl)-3-[[hydroxy-[([(2R,3S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-3-[[hydroxy-[([(2R,3S,5R)-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-3-[(phosphonooxy)methoxy]oxolan-2-yl]methoxy)phosphoryl]oxy]oxolan-2-yl]methoxy)phosphoryl]oxy]oxolan-2-yl]methoxy)phosphoryl]oxy]oxolan-2-yl]methoxyphosphonic acid; Stavudine H-phosphonate tetramer
EINECS	Contact for details

Quality Control

Our [(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-[hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxy-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methoxyphosphonic acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets exacting standards for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. Due to its hygroscopic (moisture-sensitive) nature, the container must be sealed under an inert atmosphere (argon or nitrogen) after each use and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.