Description

Benzamide, N-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-L-ribofuranosyl]-9H-purin-6-yl]- is a sophisticated, high-purity phosphoramidite monomer, a critical building block in the automated solid-phase synthesis of oligonucleotides. This compound is specifically designed for the synthesis of RNA analogs, offering precise control over nucleotide incorporation. It is an essential raw material for pharmaceutical R&D, diagnostic development, and advanced life science research, particularly in the fields of antisense therapeutics, siRNA, and mRNA technology.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer for the automated synthesis of modified RNA strands.
• Therapeutic RNA Development: Production of siRNA (small interfering RNA), antisense oligonucleotides (ASOs), and mRNA for therapeutic applications.
• Diagnostic Probes: Manufacture of labeled probes and primers for molecular diagnostics and next-generation sequencing (NGS).
• Research Reagents: Used in academic and industrial laboratories for studying gene function, regulation, and for developing novel nucleic acid-based tools.
• API Intermediate: Serves as a critical intermediate in the production of active pharmaceutical ingredients (APIs) for nucleic acid-based drugs.
• Bioconjugation: Enables the site-specific modification of oligonucleotides for targeted delivery and imaging.

Basic Information

Product Name	Benzamide, N-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-β-L-ribofuranosyl]-9H-purin-6-yl]-
CAS No.	1803193-36-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-DMT-2'-O-TBDMS-N6-Benzoyl-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite-β-L-Adenosine; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-β-L-adenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; β-L-Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-3'-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-; LNA Adenosine (Bz) Phosphoramidite (DMT, TBDMS); β-L-Adenosine phosphoramidite (Bz, DMT, 2'-O-TBDMS); Locked Nucleic Acid Adenosine Monomer (protected); RNA Synthesis Phosphoramidite (L-configuration).
EINECS	Contact for details

Quality Control

This high-value chemical is produced under strict quality control protocols, typically meeting standards suitable for pharmaceutical R&D and GMP manufacturing. Every batch is characterized using advanced analytical techniques including HPLC, 31P NMR, and 1H NMR to ensure identity, purity, and reactivity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided for each lot to guarantee batch-to-batch consistency and support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C ± 5°C under an inert atmosphere (argon or nitrogen) in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and must be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (31P NMR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Solubility	Clear, colorless solution in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.