Description

[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-[[[[(3R)-3-[2-[2-[12-(4-azido-2-nitro-phenoxy)dodecanoylsulfanyl]ethylcarbamoyl]ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propoxy]-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-4-hydroxy-oxolan-3-yl]oxyphosphonic acid is a sophisticated, high-purity nucleotide derivative engineered for advanced biochemical research and diagnostic applications. This compound is critical for researchers requiring a specialized, photo-activatable crosslinking agent for probing nucleic acid-protein interactions and biomolecular assembly. It is primarily utilized by scientists in pharmaceutical R&D, molecular biology, and diagnostic kit development who demand precise and reliable chemical tools.

Application

• Photoaffinity Labeling: Acts as a critical crosslinking reagent for studying the structure and dynamics of nucleic acid-protein complexes.
• Bioconjugation & Probe Synthesis: Used in the synthesis of advanced molecular probes for diagnostic assays and imaging.
• Structural Biology Research: Enables the mapping of binding sites and interaction networks within large biomolecular assemblies.
• Drug Discovery Platforms: Serves as a key intermediate in high-throughput screening platforms targeting nucleotide-binding proteins.
• Next-Generation Sequencing (NGS): Potential application in the development of novel sequencing chemistries and library preparation methods.
• Diagnostic Reagent Manufacturing: Incorporated into the production of specialized reagents for clinical diagnostics and life science research tools.

Basic Information

Product Name	[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-[[[[(3R)-3-[2-[2-[12-(4-azido-2-nitro-phenoxy)dodecanoylsulfanyl]ethylcarbamoyl]ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propoxy]-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-4-hydroxy-oxolan-3-yl]oxyphosphonic acid
CAS No.	130766-07-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-N-[12-(4-Azido-2-nitrophenoxy)dodecanoyl]-3'-amino-3'-deoxy-ATP; N6-(12-((4-Azido-2-nitrophenyl)oxy)dodecanoyl)-3'-amino-3'-deoxyadenosine-5'-triphosphate; 3'-Amino-3'-deoxy-ATP, N6-(12-((4-azido-2-nitrophenyl)oxy)dodecanoyl)-; Photoactivatable ATP analog; N6-(12-(4-Azido-2-nitrophenoxy)dodecanoyl)-3′-amino-3′-deoxyadenosine-5′-triphosphate; ATP-arylazido-β-alanine derivative; caged ATP analog for crosslinking; N6-([12-(4-azido-2-nitrophenoxy)dodecanoyl])-3′-amino-3′-deoxy-ATP
EINECS	Contact for details

Quality Control

Our [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-[[[[(3R)-3-[2-[2-[12-(4-azido-2-nitro-phenoxy)dodecanoylsulfanyl]ethylcarbamoyl]ethylcarbamoyl]-3-hydroxy-2,2-dimethyl-propoxy]-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxymethyl]-4-hydroxy-oxolan-3-yl]oxyphosphonic acid is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to verify identity, purity, and functional integrity. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and strictly light-sensitive; protect from all light exposure and moisture to maintain stability and reactivity. Allow the container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Functional Activity	Tested in standard crosslinking assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.