Description

[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[2-(4-hydroxyphenyl)acetyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid is a sophisticated, high-purity nucleotide derivative designed for advanced research and development. This compound is critical for applications requiring precise molecular recognition and targeted biochemical interactions, particularly in the life sciences. It is primarily utilized by pharmaceutical R&D teams, diagnostic developers, and academic researchers working on novel therapeutic agents, molecular probes, and diagnostic assays.

Application

• Pharmaceutical Research & Development: As a key intermediate or active component in the synthesis of novel nucleotide-based therapeutics, including potential antiviral or anticancer agents.
• Diagnostic Assay Development: For the design and production of high-sensitivity molecular probes and labeling reagents used in ELISA, PCR, and other detection platforms.
• Biochemical Research: As a specialized substrate or inhibitor in enzymatic studies to investigate metabolic pathways and protein-nucleotide interactions.
• Proteomics and Genomics: Utilization in the development of tools for nucleic acid labeling, sequencing, and protein binding studies.
• Antisense Technology: Potential use as a modified building block in the synthesis of antisense oligonucleotides for gene silencing applications.
• Academic Research: Serving as a critical reagent in university and institutional labs for fundamental studies in medicinal chemistry and chemical biology.

Basic Information

Product Name	[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-3-[2-[2-[2-(4-hydroxyphenyl)acetyl]sulfanylethylcarbamoyl]ethylcarbamoyl]-2,2-dimethyl-propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid
CAS No.	117411-05-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	5'-O-[N-[2-[2-[2-[(4-Hydroxyphenyl)acetylthio]ethylcarbamoyl]ethylcarbamoyl]-3-hydroxy-2,2-dimethylpropyl]phosphono]-ATP; Modified ATP derivative; Adenosine 5'-triphosphate, 2'-deoxy-2'-(phosphonomethyl)-, P'-→5'-ester with N-[2-[2-[2-[(4-hydroxyphenyl)acetylthio]ethylcarbamoyl]ethylcarbamoyl]-3-hydroxy-2,2-dimethylpropyl] phosphoramidate; Custom Nucleotide Conjugate; Thioacetyl-linked ATP analog; Phenolic ATP probe
EINECS	Contact for details

Quality Control

Our production of this high-grade nucleotide derivative adheres to strict quality management protocols. Each batch is characterized and purified using advanced chromatographic techniques to ensure exceptional purity and batch-to-batch consistency. Comprehensive Certificates of Analysis (COA) are provided, detailing specifications for identity, purity (HPLC), and related substances. We support compliance with cGMP and ISO 9001 standards for research and development materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.