Description

(8S,10S)-10-[[3-(2-Cyano-4-morpholinyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione is a complex, semi-synthetic anthracycline derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a key intermediate or reference standard for the synthesis and analytical characterization of novel chemotherapeutic agents, offering researchers a high-purity building block for targeted drug discovery. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focusing on oncology and antibiotic therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel anthracycline-based chemotherapeutic agents.
• Reference Standard: Used in analytical chemistry for method development, validation, and quality control (HPLC, LC-MS) of related drug substances and products.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of anthracyclines, their mechanism of action, and interactions with DNA topoisomerase II.
• Anticancer Drug Discovery: Acts as a lead compound or a structural template for designing new analogs with potentially improved efficacy and reduced cardiotoxicity.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and pharmacology.
• Impurity Standard: Characterized and supplied as a certified impurity standard for regulatory filing and stability testing of anthracycline APIs.

Basic Information

Product Name	(8S,10S)-10-[[3-(2-Cyano-4-morpholinyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
CAS No.	114414-57-2
Molecular Formula	C₃₂H₃₄N₂O₁₂
Molecular Weight	638.62 g/mol
Synonyms	4'-O-Tetrahydropyranyladriamycin; 4'-O-THP-doxorubicin; THP-adriamycin; (8S,10S)-10-[(2S,4S,5S,6S)-4-Amino-5-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione; 4'-O-Tetrahydropyranyl doxorubicin; Pirarubicin intermediate; Anthracycline derivative 114414-57-2
EINECS	Contact for details

Quality Control

Our (8S,10S)-10-[[3-(2-Cyano-4-morpholinyl)-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. Due to its light-sensitive and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.