Description

5,12-Naphthacenedione, 10-[(6-Deoxy-2-o-Methyl-α-L-Mannopyranosyl)Oxy]-7,8,9,10-Tetrahydro-1,8,11-Trihydroxy-8-Methyl-, (8R,10S)- is a complex, high-purity anthracycline derivative with significant pharmaceutical research potential. This compound matters as a sophisticated chemical intermediate or reference standard for the development of novel therapeutic agents, particularly in oncology. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced drug discovery and biochemical studies.

Application

• Pharmaceutical Reference Standard: Serves as a high-purity certified material for analytical method development, validation, and quality control in drug substance manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the multi-step synthesis of novel anthracycline-based chemotherapeutic agents.
• Biochemical Research: Employed as a tool compound in studies investigating DNA intercalation, topoisomerase II inhibition, and mechanisms of action for anticancer drugs.
• Academic & Discovery Chemistry: A key building block for medicinal chemists exploring structure-activity relationships (SAR) to develop new analogs with improved efficacy or reduced side effects.
• Process Development: Used in scaling up and optimizing synthetic routes for complex natural product derivatives within process chemistry teams.

Basic Information

Product Name	5,12-Naphthacenedione, 10-[(6-Deoxy-2-o-Methyl-α-L-Mannopyranosyl)Oxy]-7,8,9,10-Tetrahydro-1,8,11-Trihydroxy-8-Methyl-, (8R,10S)-
CAS No.	960622-70-2
Molecular Formula	C26H30O11
Molecular Weight	518.51 g/mol
Synonyms	10-[(6-Deoxy-2-O-methyl-α-L-mannopyranosyl)oxy]-7,8,9,10-tetrahydro-1,8,11-trihydroxy-8-methyl-(8R,10S)-5,12-naphthacenedione; 2-O-Methyl-α-L-oleandrosyl-ε-rhodomycinone; ε-Rhodomycinone 2'-O-methyl-α-L-oleandrosyl derivative; Anthracycline glycoside intermediate; (8R,10S)-10-((6-Deoxy-2-O-methyl-α-L-mannopyranosyl)oxy)-7,8,9,10-tetrahydro-1,8,11-trihydroxy-8-methyl-5,12-naphthacenedione
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and traceability. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and impurity profiles. We support development projects with materials suitable for use under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	Red to orange-red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.