Description

N6-Benzoyl-7'-Oh-n-Trityl Morpholino Adenosine is a sophisticated, protected nucleoside derivative primarily used as a critical building block in oligonucleotide synthesis, particularly for the production of Morpholino antisense oligomers. This compound is essential for researchers and manufacturers requiring high-purity intermediates to ensure the efficacy and specificity of therapeutic and diagnostic nucleic acid sequences. It is specifically designed for use in pharmaceutical R&D, biotechnology, and advanced life science applications where precise chemical modification is paramount.

Application

• Key Intermediate for Morpholino Oligonucleotide Synthesis: Serves as a protected monomer unit in the solid-phase synthesis of Morpholino antisense therapeutics and research tools.
• Pharmaceutical Research & Development: Used in the discovery and development of novel antisense drugs targeting genetic diseases, viral infections, and cancers.
• Biochemical Probe Development: Enables the creation of custom, nuclease-resistant oligonucleotide probes for gene expression analysis and functional genomics studies.
• Academic and Contract Research: A vital reagent for universities and CROs conducting cutting-edge research in molecular biology, genetics, and drug discovery.
• Precursor for Further Chemical Modification: The protected functional groups allow for selective deprotection and subsequent conjugation with labels, tags, or other bioactive molecules.

Basic Information

Product Name	N6-Benzoyl-7'-Oh-n-Trityl Morpholino Adenosine
CAS No.	956139-16-5
Molecular Formula	C46H42N6O6
Molecular Weight	774.87 g/mol
Synonyms	7'-Hydroxy-N6-benzoyl-5'-O-(triphenylmethyl)morpholino adenosine; N6-Bz-7'-OH-5'-DMT Morpholino Adenosine; 5'-O-DMT-N6-benzoyl-7'-hydroxy morpholino adenosine; Bz-7'-OH-DMT-Morpholino-A; Adenosine, N6-benzoyl-7'-hydroxy-5'-O-tritylmorpholino-; Protected Morpholino Adenosine monomer; PMO Adenosine building block
EINECS	Contact for details

Quality Control

Every batch of N6-Benzoyl-7'-Oh-n-Trityl Morpholino Adenosine is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the exacting standards required for sensitive oligonucleotide synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and mass spectrometry is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.