Description

3-(4-Bromophenyl)-3-(Trifluoromethyl)-3H-Diazirine is a specialized diazirine-based photoaffinity labeling reagent. This compound is valued for its ability to generate highly reactive carbene intermediates upon photolysis with UV or visible light, enabling the covalent cross-linking and study of biomolecular interactions. It is primarily required by researchers and manufacturers in pharmaceutical development, chemical biology, and materials science for probing protein-ligand binding sites, mapping active sites of enzymes, and developing advanced polymeric materials.

Application

• Photoaffinity Labeling (PAL): A critical tool in drug discovery for identifying and validating biological targets by covalently tagging binding proteins.
• Chemical Biology Probes: Used to synthesize probes for studying protein-protein interactions, enzyme mechanisms, and metabolic pathways.
• Proteomics Research: Facilitates the capture and identification of low-abundance or transient protein complexes.
• Materials Science Cross-linking: Employed in the surface functionalization of polymers and the creation of photo-crosslinkable hydrogels or resins.
• Bioconjugation: Serves as a photochemical handle for attaching labels, drugs, or other molecules to biomolecules.
• Structural Biology: Aids in determining the structure of ligand-receptor complexes by providing irreversible cross-links for analysis.

Basic Information

Product Name	3-(4-Bromophenyl)-3-(Trifluoromethyl)-3H-Diazirine
CAS No.	952143-02-1
Molecular Formula	C9H4BrF3N2
Molecular Weight	277.04 g/mol
Synonyms	4-Bromo-α-(trifluoromethyl)benzenemethanediaziridine; 3-(4-Bromophenyl)-3-(trifluoromethyl)diaziridine; 3-(p-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine; 4-Bromo-α-(trifluoromethyl)phenyl diazirine; TPD-Br; Photoaffinity Labeling Reagent TPD-Br; Benzene, 1-bromo-4-[(3H-diazirin-3-ylidene)(trifluoromethyl)methyl]-
EINECS	Contact for details

Quality Control

Our 3-(4-Bromophenyl)-3-(Trifluoromethyl)-3H-Diazirine is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere. Allow the container to reach room temperature in a dark environment before opening to prevent condensation and photodegradation. Keep away from heat and ignition sources.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.