Description

Npom-Caged Deoxythymidine is a specialized, photolabile derivative of the nucleoside deoxythymidine, designed for precise spatiotemporal control in biochemical research. This compound is critical for applications requiring the light-triggered release of active biomolecules, enabling high-precision studies of biological processes. It is primarily utilized by researchers and manufacturers in the fields of photochemistry, nucleotide synthesis, and advanced molecular biology, particularly for developing caged compounds and probes.

Application

• Photochemical Triggering Systems: Used as a caging group for the light-activated release of deoxythymidine or thymidine triphosphate (dTTP) in kinetic studies.
• Nucleic Acid Research: Serves as a key building block in the synthesis of photo-activatable oligonucleotides and probes for studying DNA/RNA dynamics.
• Enzymology Studies: Enables the precise temporal control of substrate availability for studying polymerase and nuclease activity.
• Development of Molecular Tools: Integral for creating advanced tools in chemical biology, such as photo-regulated primers or cross-linkers.
• Prodrug and Delivery Research: Investigated for potential use in light-activated prodrug strategies where controlled release of a nucleotide analog is required.

Basic Information

Product Name	Npom-Caged Deoxythymidine
CAS No.	942218-73-7
Molecular Formula	C₂₁H₂₅N₃O₈
Molecular Weight	447.44 g/mol
Synonyms	1-(2-Nitrophenyl)ethyl-caged Thymidine; 1-(2-Nitrophenylethyl) Thymidine; NPE-caged dT; 2-Nitrophenylethyl-caged Deoxythymidine; 5'-O-[(1-(2-Nitrophenyl)ethyl)]-2'-deoxythymidine; Thymidine, 5'-[1-(2-nitrophenyl)ethyl] ether; NPE-Thymidine; Photo-caged dT
EINECS	Contact for details

Quality Control

Our Npom-Caged Deoxythymidine is produced under stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccated conditions. This compound is strictly light-sensitive and hygroscopic; prolonged exposure to light, moisture, or elevated temperatures will lead to decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.