Description

Sieber Amide Resin is a specialized, high-performance solid-phase synthesis resin designed for the efficient production of peptides and other complex organic molecules. Its primary value lies in providing a robust and reliable polymeric support for the Fmoc solid-phase peptide synthesis (SPPS) strategy, enabling high coupling efficiency and purity. This resin is an essential tool for researchers and manufacturers in pharmaceutical development, biotechnology, and combinatorial chemistry who require precise and scalable synthesis platforms.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary support resin for the stepwise assembly of peptides using Fmoc (9-fluorenylmethoxycarbonyl) chemistry.
• Pharmaceutical R&D: Synthesis of peptide-based drug candidates, libraries for screening, and complex bioactive molecules.
• Combinatorial Chemistry: Generation of diverse compound libraries for high-throughput screening and lead optimization.
• Bioconjugation: Platform for the synthesis of peptide-oligonucleotide conjugates (POCs) or peptide-drug conjugates.
• Acid-Labile Linker: The resin features a handle that allows for cleavage of the final product under mild acidic conditions, preserving sensitive functional groups.
• Custom Oligomer Synthesis: Production of specialized peptides, peptidomimetics, and other non-natural oligomers for research and diagnostic applications.

Basic Information

Product Name	Sieber Amide Resin
CAS No.	915706-90-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Sieber Amide Resin; Sieber Amide Linker Resin; 2-Chlorotrityl Chloride Sieber Amide Resin; Fmoc-Sieber Amide Resin; 4-[(2,4-Dimethoxyphenyl)(Fmoc-amino)methyl]phenoxyacetic Acid Sieber Amide Resin; CTC Sieber Amide Resin; Peptide Synthesis Resin (Sieber Amide); Solid Support Resin for SPPS
EINECS	Contact for details

Quality Control

Our Sieber Amide Resin is manufactured under strict quality management systems to ensure batch-to-batch consistency and performance in sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including measurement of loading capacity, functional group integrity, and purity. Comprehensive Certificates of Analysis (COA) detailing all specifications and test results are provided to guarantee the material meets the high standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The resin is moisture-sensitive; keep the original container sealed under an inert atmosphere (argon or nitrogen) when not in use to maintain optimal loading capacity and reactivity.

Specification

Item	Specification
Appearance	White to off-white free-flowing beads
Loading Capacity	0.3 - 0.8 mmol/g (typical)
Particle Size	100-200 mesh
Identification (IR)	Conforms to structure
Moisture Content (KF)	< 5%
Functional Test	Passes standard Fmoc-deprotection/coupling test

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.