Description

4-Isothiocyanatophenyl α-D-Mannopyranoside is a specialized glycoside derivative where a mannose sugar is conjugated to a phenyl isothiocyanate moiety. This compound is a critical intermediate and conjugation reagent in the development of advanced glycoconjugates and targeted biochemical probes. It is primarily utilized by research institutions and pharmaceutical companies engaged in carbohydrate chemistry, immunology, and targeted drug delivery. The unique reactivity of the isothiocyanate group allows for stable thiourea bond formation with amines, making it invaluable for labeling and cross-linking applications.

Application

• Glycoconjugate Synthesis: A key building block for creating neoglycoconjugates, glycodendrimers, and carbohydrate-based polymers for biological studies.
• Bioconjugation & Labeling: Used to covalently attach mannose epitopes to proteins, peptides, antibodies, or solid surfaces for creating targeted probes and diagnostic tools.
• Lectin & Carbohydrate-Binding Studies: Essential for preparing affinity matrices and probes to study carbohydrate-protein interactions, particularly with mannose-binding lectins like DC-SIGN.
• Vaccine & Adjuvant Development: Employed in the research and development of carbohydrate-based vaccines and immunomodulators targeting antigen-presenting cells.
• Drug Delivery Systems: Facilitates the design of targeted drug delivery carriers by enabling the surface functionalization of nanoparticles or liposomes with specific carbohydrate ligands.
• Diagnostic Reagent Manufacturing: Serves as a precursor in the production of reagents for diagnostic assays, including ELISA and flow cytometry, where specific carbohydrate recognition is required.

Basic Information

Product Name	4-Isothiocyanatophenyl α-D-Mannopyranoside
CAS No.	96345-79-8
Molecular Formula	C13H15NO6S
Molecular Weight	313.33 g/mol
Synonyms	p-Isothiocyanatophenyl α-D-mannopyranoside; 4-Isothiocyanatophenyl α-D-mannoside; 1-O-(4-Isothiocyanatophenyl)-α-D-mannopyranose; Phenyl 4-isothiocyanato-α-D-mannopyranoside; Mannose-PITC; α-D-Mannopyranoside, 4-isothiocyanatophenyl; 4-ITC-Phenyl-α-D-mannopyranoside
EINECS	Contact for details

Quality Control

Our 4-Isothiocyanatophenyl α-D-Mannopyranoside is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.