Description

N(4)-Methoxydeoxycytidine Triphosphate is a chemically modified nucleotide triphosphate analog, specifically engineered for advanced molecular biology and diagnostic applications. This compound is critical for researchers requiring precise control over nucleic acid synthesis and stability, particularly in sequencing and probe development. It serves as an essential reagent for biotechnology, pharmaceutical R&D, and academic laboratories focused on genomics and molecular diagnostics.

Application

• Next-Generation Sequencing (NGS): Used as a modified dCTP analog to study polymerase kinetics, improve sequencing accuracy, or introduce termination points.
• PCR and qPCR Probe Design: Incorporation into oligonucleotide probes to enhance specificity, stability, and detection in diagnostic assays.
• Site-Directed Mutagenesis: A tool for introducing specific, controlled modifications into DNA sequences during synthesis.
• Structural Biology Studies: Employed to investigate DNA-protein interactions and enzyme mechanisms where a modified cytidine base is required.
• Diagnostic Kit Manufacturing: A key raw material in the production of kits for genetic testing, viral detection, and other molecular diagnostics.
• Antisense Oligonucleotide Synthesis: Used in the creation of modified oligonucleotides for therapeutic and research applications targeting gene expression.

Basic Information

Product Name	N(4)-Methoxydeoxycytidine Triphosphate
CAS No.	91918-34-2
Molecular Formula	C11H19N3O14P3
Molecular Weight	510.20 g/mol
Synonyms	4-Methoxy-2'-deoxycytidine-5'-triphosphate; 4-MeO-dCTP; N4-Methoxy-2'-deoxycytidine 5'-triphosphate; 2'-Deoxy-N4-methoxycytidine-5'-triphosphate; dCOMeTP; Modified dCTP; 5'-Triphosphoric acid, 2'-deoxy-4-methoxycytidine; N4-MethoxydCTP
EINECS	Contact for details

Quality Control

Our N(4)-Methoxydeoxycytidine Triphosphate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for sensitive research and diagnostic applications. Each lot is analyzed by HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities such as free nucleotides and salts. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Triethylammonium Salt Content	Reported on COA
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.