Description

P(Dc)10 Sodium Salt, 5'-Phosphorylated is a chemically defined, high-purity oligonucleotide intermediate. This compound is critical for ensuring the precise and reproducible synthesis of oligonucleotides, where the 5'-phosphate group is essential for downstream ligation and labeling reactions. It is primarily required by manufacturers and research institutions in the fields of molecular diagnostics, therapeutic oligonucleotide development, and advanced life science research.

Application

• Therapeutic Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of antisense oligonucleotides, siRNA, and aptamers.
• Molecular Diagnostics: Used in the production of primers and probes for PCR, qPCR, and next-generation sequencing applications.
• Fluorescent Labeling: Serves as a starting material for the conjugation of fluorophores or other reporter molecules to oligonucleotides.
• Ligation Substrates: The 5'-phosphorylated terminus enables efficient enzymatic ligation for gene assembly and cloning workflows.
• Research & Development: Employed in academic and industrial R&D for studying nucleic acid interactions, enzyme mechanisms, and developing novel assays.
• GMP Manufacturing: Supports the production of clinical-grade oligonucleotide active pharmaceutical ingredients (APIs) under controlled conditions.

Basic Information

Product Name	P(Dc)10 Sodium Salt, 5'-Phosphorylated
CAS No.	90385-76-5
Molecular Formula	C100H121N30O61P11Na11 (estimated)
Molecular Weight	~3300 g/mol (estimated)
Synonyms	5'-Phosphorylated dC10 Sodium Salt; Deca-2'-deoxycytidylyl-(3'→5')-2'-deoxycytidine 5'-(dihydrogen phosphate) undecasodium salt; pdC(pdC)9; Oligodeoxycytidylic acid, 5'-phosphate, sodium salt; dC10 5'-monophosphate; 5'-Phospho-dC10; Phosphorylated Oligodeoxycytidine (10-mer); P(dC)10
EINECS	Contact for details

Quality Control

Every batch of P(Dc)10 Sodium Salt, 5'-Phosphorylated is manufactured and tested to meet stringent quality standards suitable for critical research and GMP applications. Our quality system ensures identity, purity, and consistency. Comprehensive analysis includes HPLC for purity and assay, mass spectrometry (MS) for identity and sequence confirmation, and tests for moisture and endotoxin levels where required. A Certificate of Analysis (COA) detailing all specifications and results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider desiccant.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference
Assay (HPLC)	≥ 95%
Purity (HPLC)	≥ 90% (Full-length product)
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg (on request)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.