Description

1-(5-o-(Dimethoxytrityl)-β-D-2-Deoxyribofuranosyl)-5-Nitroindole is a high-purity, protected nucleoside phosphoramidite precursor, a critical building block in automated oligonucleotide synthesis. Its value lies in enabling the precise, large-scale production of modified DNA and RNA sequences for advanced research and therapeutic applications. This compound is essential for pharmaceutical R&D, diagnostic assay developers, and biotechnology companies working on antisense oligonucleotides, aptamers, and other nucleic acid-based technologies.

Application

• Oligonucleotide Synthesis: Serves as a key phosphoramidite monomer for the solid-phase synthesis of DNA strands containing modified bases.
• Antisense Drug Development: Used in the research and production of antisense oligonucleotides (ASOs) for therapeutic applications targeting genetic diseases.
• Diagnostic Probe Manufacture: Integral for creating labeled probes and primers used in PCR, sequencing, and microarray technologies.
• Aptamer Research: Enables the synthesis of SELEX libraries and specific aptamers for biomarker detection and targeted drug delivery.
• Basic Biochemical Research: Employed in academic and industrial labs to study nucleic acid structure, function, and protein interactions.
• Synthesis of Modified Nucleosides: Acts as a versatile intermediate for further chemical modifications to create novel nucleoside analogs.

Basic Information

Product Name	1-(5-o-(Dimethoxytrityl)-β-D-2-Deoxyribofuranosyl)-5-Nitroindole
CAS No.	869355-18-0
Molecular Formula	C34H33N3O7
Molecular Weight	595.65 g/mol
Synonyms	5-Nitroindole-2'-deoxyriboside, DMT-protected; 5-Nitroindole dA (dmf) Phosphoramidite (precursor); 1-[5-O-(4,4'-Dimethoxytrityl)-β-D-2-deoxyribofuranosyl]-5-nitro-1H-indole; 5-Nitroindole-2'-deoxyriboside 5'-O-DMT; DMT-dI5-NO2; 5-Nitroindole deoxyribonucleoside derivative; 1-(5-O-Dimethoxytrityl-β-D-2-deoxyribofuranosyl)-5-nitroindole
EINECS	Contact for details

Quality Control

Our 1-(5-o-(Dimethoxytrityl)-β-D-2-Deoxyribofuranosyl)-5-Nitroindole is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. We adhere to cGMP guidelines where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in acetonitrile, DCM, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.