Description

2-Amino-5'-o-(Dimethoxytrityl)-2'-Deoxy-N6-(Dimethylaminomethylidene)-N2-(Isobutyryl)Adenosine is a sophisticated, protected nucleoside derivative essential for advanced oligonucleotide synthesis. This compound serves as a critical building block for the solid-phase assembly of modified DNA and RNA sequences, enabling precise control over genetic material. It is primarily required by research institutions, pharmaceutical developers, and biotechnology companies engaged in antisense therapy, siRNA development, and diagnostic probe manufacturing.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the automated solid-phase synthesis of DNA and RNA strands.
• Antisense Drug Development: Used in creating therapeutic oligonucleotides designed to target and modulate specific gene expression.
• siRNA and miRNA Research: Essential for constructing short interfering RNA (siRNA) and microRNA (miRNA) molecules for gene silencing studies.
• Diagnostic Probe Fabrication: Employed in the production of labeled probes for fluorescence in situ hybridization (FISH) and other molecular diagnostics.
• Structural Biology Studies: Utilized to incorporate modified adenosine residues into nucleic acids for studying structure-function relationships.
• Synthesis of Aptamers: A building block for generating high-affinity nucleic acid aptamers used in therapeutics and sensors.

Basic Information

Product Name	2-Amino-5'-o-(Dimethoxytrityl)-2'-Deoxy-N6-(Dimethylaminomethylidene)-N2-(Isobutyryl)Adenosine
CAS No.	869354-77-8
Molecular Formula	C43H49N7O7
Molecular Weight	775.90 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-(dimethylaminomethylene)-2'-deoxy-2-(isobutyrylamino)adenosine; DMTr-dAib-DMF Amidite Precursor; N6-DMF-2'-Deoxy-2-N-Isobutyryladenosine-5'-O-DMTr; 2'-Deoxy-5'-O-DMTr-N6-DMF-2-N-Ibu-Adenosine; Protected 2-Aminoadenosine Derivative; DNA Synthesis Building Block; 2-NH2-dA(DMF,Ibu)-DMTr
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch of 2-Amino-5'-o-(Dimethoxytrityl)-2'-Deoxy-N6-(Dimethylaminomethylidene)-N2-(Isobutyryl)Adenosine is analyzed to meet stringent specifications for purity and identity, suitable for sensitive pharmaceutical and research applications. Certificates of Analysis (COA) with detailed HPLC, NMR, and mass spectrometry data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.