Description

5'-O-DMT-N6-Benzoyl-2'-Deoxyadenosine CEP is a high-purity, protected nucleoside phosphoramidite building block essential for automated oligonucleotide synthesis. This compound is critical for ensuring high coupling efficiency and sequence fidelity in the production of DNA strands. It is primarily required by manufacturers and research institutions in the pharmaceutical, biotechnology, and diagnostic sectors for applications in antisense therapy, PCR primers, and genetic research.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer for the solid-phase synthesis of DNA sequences.
• Therapeutic Oligonucleotide Production: Manufacturing of antisense oligonucleotides, siRNA, and aptamers for drug development.
• Research & Diagnostic Probes: Synthesis of labeled probes and primers for PCR, sequencing, and genetic analysis.
• Genomic Studies: Used in academic and industrial research for constructing gene fragments and studying nucleic acid interactions.
• CRISPR/Cas9 Component Synthesis: Production of guide RNA (gRNA) components and other synthetic nucleic acids for gene editing applications.

Basic Information

Product Name	5'-O-DMT-N6-Benzoyl-2'-Deoxyadenosine CEP
CAS No.	865758-44-7
Molecular Formula	C47H51N6O7P
Molecular Weight	818.93 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; dA(Bz) Phosphoramidite; 2'-Deoxyadenosine, N6-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; N6-Benzoyl-2'-deoxyadenosine-5'-O-DMT-3'-CEP; dABz CE Phosphoramidite; Adenosine, 2'-deoxy-N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-, 3'-[2-cyanoethyl (N,N-diisopropyl)phosphoramidite]
EINECS	Contact for details

Quality Control

Our 5'-O-DMT-N6-Benzoyl-2'-Deoxyadenosine CEP is manufactured under strict quality systems to meet the exacting standards of oligonucleotide synthesis. Each batch is subjected to rigorous analytical testing, including HPLC for purity and 31P NMR for structural confirmation, to ensure optimal performance in automated synthesizers. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C under an inert atmosphere (argon or nitrogen) in a desiccated environment. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will degrade product quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (31P NMR)	Conforms
Purity (HPLC)	≥ 98.5%
Moisture Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.