Description

Polydeoxyadenylic Acid-Polythymidylic Acid Sodium Salt is a synthetic, double-stranded DNA polymer consisting of alternating deoxyadenylic and thymidylic acid residues. This compound serves as a critical model system and reagent in molecular biology research, particularly for studying nucleic acid interactions, enzyme kinetics, and polymerase activity. It is essential for research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in genomics, virology, and the development of nucleic acid-based therapeutics.

Application

• Molecular Biology Research: Used as a standard template or substrate in studies of DNA polymerases, nucleases, and helicases to understand replication and repair mechanisms.
• Diagnostic Assay Development: Serves as a control or calibrator in PCR (Polymerase Chain Reaction) and other nucleic acid amplification tests (NAATs) for infectious diseases and genetic disorders.
• Biochemical Reagent: Employed in binding studies to investigate the interactions between DNA and proteins, drugs, or other small molecules.
• Enzyme Activity Testing: Acts as a specific substrate for assaying the activity and fidelity of reverse transcriptase and other DNA-modifying enzymes.
• Virology and Antiviral Research: Utilized as a model for viral DNA synthesis in the screening and evaluation of potential antiviral compounds.
• Academic & Industrial R&D: Fundamental tool in university laboratories and biotech R&D departments for foundational research in genetics and molecular biology.

Basic Information

Product Name	Polydeoxyadenylic Acid-Polythymidylic Acid Sodium Salt
CAS No.	86834-22-2
Molecular Formula	(C10H12N5O6P • C10H13N2O8P)n • xNa
Molecular Weight	Variable (Polymer)
Synonyms	Poly(dA-dT) Sodium Salt; Poly(deoxyadenylic-deoxythymidylic) Acid Sodium Salt; Poly(dA-dT); Poly(dA-dT) Sodium Salt; Alternating Copolymer d(A-T)n; Polydeoxyadenylate-thymidylate Sodium Salt; DNA Polymer (dA-dT); d(A-T)n Copolymer
EINECS	Contact for details

Quality Control

Our Polydeoxyadenylic Acid-Polythymidylic Acid Sodium Salt is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes rigorous analytical testing. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and bioburden is provided, confirming compliance with stringent in-house specifications. We support research-grade and potential GMP-grade requirements upon inquiry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White or off-white fibrous solid or lyophilized powder
Identification (UV, HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 95% (Polymer Content)
Base Ratio (A:T)	~1:1 (by UV or HPLC analysis)
Molecular Size (SEC/GPC)	Specified range available (e.g., 500-5000 base pairs)
Absorbance Ratio (A260/A280)	1.8 - 2.0
pH (in solution)	6.5 - 7.5
Endotoxin	< 10 EU/mg (for applicable grades)
Bioburden	To specified limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.