Description

Poly(Deoxy(Adenylic Acid-Thymidine 5'-o-Phosporothioate)) CAS NO 86550-16-5 is a synthetic oligonucleotide analog featuring a phosphorothioate backbone, which confers enhanced nuclease resistance compared to natural phosphodiester linkages. This chemical modification is critical for applications requiring prolonged stability and bioavailability in biological systems. It is primarily utilized by researchers and developers in the fields of therapeutic oligonucleotide synthesis, molecular biology, and diagnostic probe development.

Application

• Antisense Oligonucleotide (ASO) Synthesis: Serves as a key building block for creating therapeutic agents that modulate gene expression.
• siRNA and miRNA Research: Used in the construction of stabilized guide strands for RNA interference studies.
• Diagnostic Probe Development: Essential for creating nuclease-resistant probes for in situ hybridization and other detection assays.
• Apoptamer and DNAzyme Construction: Provides backbone stability for functional nucleic acids used in biosensing and therapeutics.
• PCR and Sequencing Primers: Incorporated to enhance the durability and performance of primers in demanding applications.
• Bioconjugation and Labeling: Acts as a substrate for attaching reporter molecules like fluorophores or quenchers.
• Structural Biology Studies: Employed to investigate nucleic acid-protein interactions with improved stability.
• Pharmaceutical Intermediate: A critical raw material in the GMP-compliant manufacturing of oligonucleotide-based drugs.

Basic Information

Product Name	Poly(Deoxy(Adenylic Acid-Thymidine 5'-o-Phosporothioate))
CAS No.	86550-16-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Poly(dA-dT) Phosphorothioate; PS-Oligo(dA-dT); Phosphorothioate-linked Poly(dA-dT); Polydeoxyadenylyl-thymidylic acid phosphorothioate; d(AT) Phosphorothioate Polymer; Antisense Oligonucleotide Polymer (dA-dT); Poly[d(A-T)] with Phosphorothioate Linkage; Stabilized Polydeoxyadenosine-Thymidine Oligomer
EINECS	Contact for details

Quality Control

Our Poly(Deoxy(Adenylic Acid-Thymidine 5'-o-Phosporothioate)) is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and nuclease resistance assays to ensure performance. Certificates of Analysis (COA) detailing purity, endotoxin levels, and other critical parameters are available upon request. We support development from research to cGMP-grade production.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep under inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Phosphorothioate Linkage Content	≥ 98%
Endotoxin Level	< 10 EU/mg
Moisture Content (KF)	< 5.0%
Solubility	Soluble in water, TE buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.