Description

Poly(8-Methyladenylic Acid) CAS NO 86456-35-1 is a synthetic polynucleotide analog derived from adenosine, where the 8-position of the adenine base is methylated. This specific chemical modification is crucial for research into nucleic acid structure, stability, and protein interactions, offering unique properties compared to its unmodified counterpart. It is primarily utilized by biochemists, molecular biologists, and pharmaceutical researchers in advanced life science and drug discovery applications.

Application

• Biochemical Research: Used as a model compound to study the effects of base methylation on RNA/DNA duplex stability, conformation, and recognition by enzymes.
• Enzyme Substrate & Inhibition Studies: Serves as a specific substrate or inhibitor for nucleases, polymerases, and methyltransferases to elucidate enzymatic mechanisms.
• Structural Biology: Incorporated into oligonucleotides for X-ray crystallography or NMR studies to investigate nucleic acid-protein complex structures.
• Antisense & Therapeutic Oligonucleotide Development: Acts as a building block for synthesizing modified oligonucleotides with enhanced nuclease resistance and binding affinity for target validation and therapeutic candidate screening.
• Diagnostic Probe Development: Utilized in the design of high-specificity probes for detecting genetic sequences, where methylation can alter hybridization kinetics.
• Aptamer Engineering: Employed in SELEX (Systematic Evolution of Ligands by Exponential Enrichment) processes to generate nucleic acid aptamers with improved stability and binding properties.

Basic Information

Product Name	Poly(8-Methyladenylic Acid)
CAS No.	86456-35-1
Molecular Formula	(C11H14N5O6P)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(8-Methyladenosine 5'-monophosphate); Poly(8-Methyl-AMP); 8-Methyladenylic Acid Homopolymer; Poly(8-MeA); Poly(8-methyladenosine phosphate); Poly(8-methyl-5'-adenylic acid); 8-Methylpolyadenylic acid
EINECS	Contact for details

Quality Control

Our Poly(8-Methyladenylic Acid) is produced under stringent conditions to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as polymer length distribution, base composition, and purity. We adhere to rigorous internal quality standards to support the reliability required in pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at low temperature. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (UV/VIS)	Characteristic spectrum of 8-methyladenine
Identification (HPLC)	Consistent with reference standard
Purity (HPLC)	≥ 95% (Polymer peak)
Base Ratio (8-MeA:A)	≥ 98:2
Average Chain Length (n)	Contact for details
Solubility	Soluble in aqueous buffers, DMSO (limited)
Endotoxin Level	< 10 EU/mg (if specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.