Description

2-Hydroxyaclacinomycin B is a chemically modified derivative of the anthracycline antibiotic aclacinomycin A, offering distinct biochemical properties. This compound is valued in research and development for its potential as a key intermediate or reference standard in the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology and antibiotic discovery.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate in the synthesis of novel anthracycline-based chemotherapeutic agents.
• Biochemical Research: Used as a reference standard in studies investigating the structure-activity relationships (SAR) of anthracycline antibiotics.
• Oncology Studies: Employed in preclinical research to explore modified anthracyclines with potentially improved efficacy or reduced cardiotoxicity.
• Antibiotic Mechanism Studies: Acts as a tool compound for researching the interaction of anthracyclines with DNA and topoisomerase II.
• Analytical Standard: Used in quality control laboratories for the identification and quantification of aclacinomycin derivatives via HPLC or LC-MS methods.

Basic Information

Product Name	2-Hydroxyaclacinomycin B
CAS No.	85819-82-5
Molecular Formula	C₄₂H₅₃NO₁₆
Molecular Weight	851.87 g/mol
Synonyms	2'-Hydroxyaclacinomycin B; 2'-OH-Aclacinomycin B; 2'-Hydroxyaclacinomycin A; BA-180265; Aclacinomycin B, 2'-hydroxy-; 2'-Hydroxy-Aclacinomycin A
EINECS	Contact for details

Quality Control

Our 2-Hydroxyaclacinomycin B is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing batch-specific results against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.