Description

Polydeoxyadenylic Acid Sodium Salt is a synthetic polynucleotide composed of deoxyadenosine monophosphate units, widely utilized as a critical reagent in molecular biology and biochemical research. Its primary value lies in its role as a defined-sequence nucleic acid polymer for hybridization studies, enzyme substrate analysis, and the development of diagnostic assays. This high-purity biochemical is essential for research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers focused on genetics, virology, and nucleic acid chemistry.

Application

• Molecular Biology Research: Used as a template, primer, or substrate in enzymatic reactions involving DNA polymerases, nucleases, and ligases.
• Hybridization Studies: Serves as a control or competitor in Southern, Northern, and dot-blot hybridization experiments to study nucleic acid interactions.
• Diagnostic Assay Development: Employed in the calibration and validation of PCR-based tests, biosensors, and other nucleic acid detection platforms.
• Biochemical Standard: Acts as a quantitative standard for spectrophotometric and fluorometric analysis of DNA concentration and purity.
• Polymerase Chain Reaction (PCR): Can be used as a non-specific carrier DNA or in optimization protocols for amplification efficiency.
• Structural Studies: Utilized in biophysical research to investigate the conformation, stability, and ligand-binding properties of single-stranded DNA.

Basic Information

Product Name	Polydeoxyadenylic Acid Sodium Salt
CAS No.	85578-95-6
Molecular Formula	(C10H12N5O6P)n • xNa
Molecular Weight	Variable (Polymer)
Synonyms	Poly(dA) sodium salt; Poly(deoxyadenylic acid) sodium salt; dA Homopolymer sodium salt; Polydeoxyadenylate sodium; Poly(deoxyadenosine phosphate) sodium salt; Poly(dA); Polydeoxyadenylic acid
EINECS	Contact for details

Quality Control

Our Polydeoxyadenylic Acid Sodium Salt is manufactured under controlled conditions to ensure batch-to-batch consistency suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including assessment of purity, chain length, and absence of nucleases. A comprehensive Certificate of Analysis (COA) detailing specifications such as A260/A280 ratio, melting temperature (Tm), and endotoxin levels is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (UV-Vis)	Characteristic absorption spectrum of poly(dA)
Purity (HPLC)	≥ 95% (Polymer peak)
A260/A280 Ratio	1.8 - 2.0 (in buffer)
Chain Length (n)	Specified (e.g., 12-18mer, 20-30mer, or >50mer)
Solubility	Soluble in TE buffer or nuclease-free water
Endotoxin	< 10 EU/mg (for molecular biology grade)
Nuclease Activity	Not detected

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.