Description

Bz-Dmt-Deoxyadenosine 2-Clph Diester Triethylammonium Salt is a specialized, high-purity nucleoside phosphoramidite derivative, a critical building block in the automated synthesis of oligonucleotides. This compound matters for its role in enabling the precise and efficient construction of DNA sequences for research, diagnostics, and therapeutic development. It is primarily needed by biotechnology and pharmaceutical companies engaged in molecular biology, genetic research, and the production of antisense oligonucleotides and primers.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer in solid-phase automated DNA/RNA synthesizers.
• Antisense Drug Development: For the research and production of antisense oligonucleotides targeting specific genes.
• PCR Primer Manufacturing: Used in the synthesis of custom primers for polymerase chain reaction (PCR) applications.
• Genetic Research Probes: Essential for creating labeled or modified DNA probes used in hybridization and sequencing.
• Therapeutic Nucleic Acid Production: A precursor in the synthesis of siRNA, aptamers, and other therapeutic nucleic acids.
• Diagnostic Kit Component: Used in the manufacture of components for molecular diagnostic assays and kits.

Basic Information

Product Name	Bz-Dmt-Deoxyadenosine 2-Clph Diester Triethylammonium Salt
CAS No.	85381-22-2
Molecular Formula	C₄₈H₅₈ClN₆O₈P • C₆H₁₅N
Molecular Weight	~1000.5 g/mol (Free acid), ~1157.3 g/mol (Triethylammonium salt)
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-deoxyadenosine-3'-[(2-chlorophenyl)-2-cyanoethyl-N,N-diisopropylphosphoramidite] Triethylammonium Salt; dA(Bz) Phosphoramidite (DMT-on); N6-Benzoyl-2'-deoxyadenosine-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-cyanoethyl-N,N-diisopropylphosphoramidite) 2-Chlorophenyl Ester; 2'-Deoxyadenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[[[2-cyanoethoxy([(1,1-dimethylethyl)amino]phosphino]oxy]-2-chlorophenyl] ester; Bz-dA-CE Phosphoramidite; Adenosine, 2'-deoxy-N-benzoyl-, 5'-[bis(4-methoxyphenyl)phenylmethyl] 3'-[2-chlorophenyl [2-cyanoethoxy(diisopropylamino)phosphino]ate]
EINECS	Contact for details

Quality Control

Our Bz-Dmt-Deoxyadenosine 2-Clph Diester Triethylammonium Salt is manufactured under strict quality systems suitable for pharmaceutical and molecular biology applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and reliability. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee the material meets the stringent requirements for oligonucleotide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a desiccated environment. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or foam
Identification (HPLC)	Conforms to reference standard
Identification (³¹P NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in anhydrous acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.