Description

Bromo(Phenyl-D5)Magnesium is a deuterated Grignard reagent, specifically the bromo(pentadeuteriophenyl)magnesium derivative, with CAS number 84783-81-3. This compound is a critical tool for introducing a stable, isotopically labeled phenyl group into target molecules, enabling precise tracking and analysis in research and development. It is primarily utilized by scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications requiring deuterium labeling, such as in the synthesis of internal standards, mechanistic studies, and the development of novel active compounds.

Application

• Deuterated Pharmaceutical Intermediate Synthesis: A key building block for creating deuterium-labeled drug candidates and active pharmaceutical ingredients (APIs) to study metabolic pathways and improve pharmacokinetic profiles.
• Internal Standard Production: Essential for synthesizing high-purity, isotopically labeled internal standards used in quantitative mass spectrometry (LC-MS, GC-MS) for accurate bioanalysis and drug metabolism studies.
• Mechanistic & Metabolic Research: Used in tracer studies to investigate reaction mechanisms and metabolic fate of compounds in biological systems, leveraging the kinetic isotope effect (KIE).
• Agrochemical Development: Employed in the research and synthesis of novel, labeled agrochemicals to study environmental fate, degradation pathways, and mode of action.
• Advanced Material Science: Serves as a precursor for introducing deuterated phenyl groups into organic semiconductors, liquid crystals, and polymers to modify electronic properties and enhance stability.
• NMR Spectroscopy Aids: Used to prepare compounds that simplify complex NMR spectra by reducing signal overlap, aiding in structural elucidation.

Basic Information

Product Name	Bromo(Phenyl-D5)Magnesium
CAS No.	84783-81-3
Molecular Formula	C6D5MgBr
Molecular Weight	181.33 g/mol
Synonyms	Magnesium, bromo(pentadeuteriophenyl)-; (Pentadeuteriophenyl)magnesium bromide; Bromo(pentadeuteriophenyl)magnesium; Phenyl-d5 magnesium bromide; Grignard reagent, C6D5MgBr; Deuterated phenylmagnesium bromide; (2H5)Phenylmagnesium bromide; Bromo(2,3,4,5,6-pentadeuteriophenyl)magnesium
EINECS	Contact for details

Quality Control

Our Bromo(Phenyl-D5)Magnesium is manufactured under strict quality protocols to ensure high isotopic purity and chemical consistency, critical for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay (by titration), isotopic enrichment (by NMR or MS), and solution concentration/quality. We adhere to cGMP principles where applicable to support our clients in regulated development environments.

Storage

Preserve in a tightly closed container, protected from light. This material is highly volatile, hygroscopic (moisture-sensitive), and easily oxidized. It must be stored under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. For solutions, typical recommended storage temperature is 2-8°C. Keep away from heat, sparks, open flames, and incompatible materials such as strong acids, water, and oxidizing agents.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light brown
Concentration (in THF or Ether)	0.5 M - 1.0 M (Custom concentrations available)
Assay (Titration)	≥ 95%
Isotopic Enrichment (D-content)	≥ 98 atom % D
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.