Description

(3 5 Bis(Trifluoromethyl)Phenyl)Magnesium Bromide is a highly reactive Grignard reagent featuring a perfluorinated aromatic ring system. This compound matters as a critical building block for introducing the electron-deficient, lipophilic 3,5-bis(trifluoromethyl)phenyl group into complex molecular architectures. It is essential for researchers and manufacturers in pharmaceutical development, agrochemical synthesis, and advanced materials science who require precise functionalization to modulate the electronic and physical properties of their target molecules.

Application

• Pharmaceutical Intermediates: Key reagent for synthesizing active pharmaceutical ingredients (APIs) where the CF3 group enhances metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the group's lipophilicity and biological activity.
• Ligand and Catalyst Development: Crucial for creating specialized phosphine and N-heterocyclic carbene (NHC) ligands used in transition metal catalysis.
• Advanced Material Precursors: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers with tailored electronic properties.
• Fluorine Chemistry Research: A fundamental tool in organofluorine chemistry for studying structure-activity relationships and developing new fluorination methodologies.
• Cross-Coupling Reactions: Serves as a nucleophilic coupling partner in Kumada, Negishi, and related cross-coupling reactions to form biaryl and other carbon-carbon bonds.

Basic Information

Item	Details
Product Name	(3 5 Bis(Trifluoromethyl)Phenyl)Magnesium Bromide
CAS No.	112981-69-8
Molecular Formula	C8H3BrF6Mg
Molecular Weight	301.31 g/mol
Synonyms	[3,5-Bis(trifluoromethyl)phenyl]magnesium bromide; 1-Bromo-3,5-bis(trifluoromethyl)benzene magnesium derivative; 3,5-Bis(trifluoromethyl)phenylmagnesium bromide; Grignard reagent, [3,5-(CF3)2C6H3]MgBr; Magnesium, bromo[3,5-bis(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our (3 5 Bis(Trifluoromethyl)Phenyl)Magnesium Bromide is manufactured under stringent quality systems. Each batch undergoes rigorous analytical testing, including titration for active Grignard concentration and analysis of key impurities, to ensure consistency and reliability for sensitive synthetic applications. Certificates of Analysis (COA) documenting purity, concentration, and solvent are available upon request, supporting compliance in cGMP and ISO environments.

Storage

Preserve in a tightly closed container, protected from light. This product is easily oxidized (store under inert atmosphere) and highly volatile. It must be stored under a dry, inert atmosphere (argon or nitrogen) in a cool, well-ventilated area, away from heat and moisture sources. For extended stability, storage at 2-8°C is recommended. Always use appropriate handling techniques for air- and moisture-sensitive reagents.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (in THF or Ether)	0.5 M - 1.0 M (Custom concentrations available)
Assay (Titration)	≥ 95% (as Grignard reagent)
Identification (IR / NMR)	Conforms to structure
Solvent	Specified (Tetrahydrofuran or Diethyl ether)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.