Description

Dimethylphenylsilylmethylmagnesium Chloride, 0.50 M In 2-Methyltetrahydrofuran is a versatile organometallic reagent, specifically a Grignard reagent, supplied as a standardized solution for precise synthetic applications. This compound is highly valued for its role as a robust nucleophile and carbon nucleophile source, enabling the efficient introduction of the dimethyl(phenyl)silylmethyl group into target molecules. It is an essential building block for researchers and process chemists in pharmaceutical development, agrochemical synthesis, and advanced material science, where it facilitates key carbon-silicon bond-forming reactions.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for introducing silicon-containing functional groups into drug candidates, particularly in the development of protease inhibitors and other bioactive molecules.
• Agrochemical Production: Used in the synthesis of novel pesticides and herbicides where the silylmethyl moiety can enhance stability or biological activity.
• Material Science & Polymer Chemistry: Serves as a monomer or cross-linking agent in the creation of silicon-modified polymers, resins, and specialty silicones with tailored properties.
• Organic Synthesis & Methodology Development: A fundamental tool for constructing complex organic molecules, used in nucleophilic addition reactions to carbonyl compounds and in cross-coupling protocols.
• Ligand & Catalyst Preparation: Employed in the synthesis of sophisticated organosilicon ligands for transition metal catalysis.
• Chemical Research (Academic & Industrial): A critical reagent for exploring new synthetic pathways and reaction mechanisms in organometallic chemistry.

Basic Information

Item	Detail
Product Name	Dimethylphenylsilylmethylmagnesium Chloride, 0.50 M In 2-Methyltetrahydrofuran
CAS No.	107735-20-6
Molecular Formula	C9H13ClMgSi (for the Grignard reagent)
Molecular Weight	208.95 g/mol (for the Grignard reagent)
Synonyms	(Chloromagnesio)methyl(dimethyl)(phenyl)silane; (Dimethylphenylsilyl)methylmagnesium Chloride; Dimethyl(phenyl)silylmethylmagnesium Chloride; Grignard Reagent (Dimethylphenylsilylmethyl-); (Phenyldimethylsilyl)methylmagnesium Chloride; 2-Methf Solution of Dimethylphenylsilylmethylmagnesium Chloride; (Dimethyl(phenyl)silyl)methylmagnesium Chloride
EINECS	Contact for details

Quality Control

Every batch of our Dimethylphenylsilylmethylmagnesium Chloride solution is manufactured and tested under stringent quality protocols to ensure consistency and reliability for your critical syntheses. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing key parameters such as concentration (by titration), solvent purity, and absence of major impurities. Our quality system is designed to meet the exacting standards of GMP and ISO-guided environments for research and production.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C (refrigerated) to maintain solution stability and potency. The product is highly volatile, easily oxidized, and moisture-sensitive; all handling and aliquoting must be performed using standard Schlenk-line or glovebox techniques under a dry, inert gas to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to light yellow solution
Concentration	0.50 M in 2-Methyltetrahydrofuran
Assay (Titration)	0.45 - 0.55 M
Solvent (2-MeTHF) Purity	> 99.5% (GC)
Water Content (Karl Fischer)	< 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.