Description

2,4,6-Triisopropylphenylmagnesium Bromide, 0.50 M In Thf is a highly reactive Grignard reagent solution, essential for introducing the bulky, electron-rich 2,4,6-triisopropylphenyl group into target molecules. This sterically hindered organometallic compound is a critical building block for advanced organic synthesis, enabling the creation of complex ligands, functional materials, and pharmaceutical intermediates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to modify molecular properties and develop novel compounds.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing sterically hindered biaryl systems and complex molecular scaffolds in active pharmaceutical ingredient (API) development.
• Ligand Precursor for Catalysis: Serves as a starting material for synthesizing bulky phosphine and N-heterocyclic carbene (NHC) ligands used in cross-coupling and hydrogenation catalysts.
• Material Science Research: Employed in the synthesis of novel organic electronic materials, including charge-transport molecules and luminescent compounds.
• Agrochemical Development: Used to create advanced active ingredients with tailored steric and electronic properties for crop protection.
• Fine Chemical Manufacturing: Facilitates the production of specialty chemicals requiring the incorporation of a highly substituted phenyl group.
• Academic & Industrial R&D: A valuable tool for methodological development in organometallic chemistry and new reaction discovery.

Basic Information

Product Name	2,4,6-Triisopropylphenylmagnesium Bromide, 0.50 M In Thf
CAS No.	108894-99-1
Molecular Formula	C15H23BrMg
Molecular Weight	283.55 g/mol (for the bromide salt)
Synonyms	2,4,6-Triisopropylphenylmagnesium Bromide solution; (2,4,6-Triisopropylphenyl)magnesium bromide; Magnesium, bromo(2,4,6-triisopropylphenyl)-; Tris(1-methylethyl)phenylmagnesium bromide; TipMgBr; 2,4,6-Triisopropylphenyl Grignard reagent; 2,4,6-Triisopropylphenylmagnesium Bromide THF solution; 2,4,6-Triisopropylphenylmagnesium Bromide 0.5M in THF
EINECS	Contact for details

Quality Control

Every batch of our 2,4,6-Triisopropylphenylmagnesium Bromide solution is manufactured and tested under strict inert atmosphere conditions to ensure consistency and reactivity. We employ advanced analytical techniques, including titration (Karl Fischer, GC) and spectroscopic methods, to verify concentration, purity, and the absence of deleterious impurities. Certificates of Analysis (COA) detailing batch-specific results are provided and confirm compliance with our stringent internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dedicated flammable solvents cabinet. The solution is highly volatile and easily oxidized; ensure containers are securely sealed and only opened in a moisture-free environment. Keep away from heat, sparks, open flames, and strong oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration	0.50 M in Tetrahydrofuran (THF)
Assay (Titration)	0.48 - 0.52 M
Water Content (Karl Fischer)	< 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.