Description

4-Methyl-2-Pyridylmagnesium Bromide is a versatile organometallic reagent, specifically a Grignard reagent, widely used in organic synthesis. Its primary value lies in its ability to act as a powerful nucleophile for the formation of carbon-carbon bonds, enabling the construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it serves as a key building block for active pharmaceutical ingredients (APIs), specialty chemicals, and functional materials.

Application

• As a critical nucleophile in pharmaceutical intermediate synthesis, particularly for introducing the 4-methyl-2-pyridyl moiety into target molecules.
• Used in cross-coupling reactions (e.g., Kumada coupling) to create biaryl structures common in drug discovery.
• Employed in the synthesis of ligands for catalysts and metal-organic frameworks (MOFs).
• Facilitates alkylation and arylation reactions in fine chemical production.
• Acts as a building block for agrochemical active ingredients, such as herbicides and fungicides.
• Utilized in academic and industrial R&D for methodological development and novel compound library generation.
• Applied in the synthesis of functionalized pyridine derivatives used in electronic materials and corrosion inhibitors.

Basic Information

Product Name	4-Methyl-2-Pyridylmagnesium Bromide
CAS No.	113170-67-5
Molecular Formula	C6H6BrMgN
Molecular Weight	196.32 g/mol
Synonyms	2-(4-Methylpyridyl)magnesium bromide; (4-Methyl-2-pyridinyl)magnesium bromide; 4-Methyl-2-pyridylmagnesium bromide solution; 4-Methylpyrid-2-ylmagnesium bromide; 2-Pyridylmagnesium bromide, 4-methyl-; Magnesium, bromo(4-methyl-2-pyridyl)-; Grignard reagent, 4-methyl-2-pyridylmagnesium bromide
EINECS	Contact for details

Quality Control

Our production of 4-Methyl-2-Pyridylmagnesium Bromide adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is analyzed to confirm identity, purity, and concentration (typically supplied as a solution in THF or diethyl ether). Certificates of Analysis (COA) documenting key parameters are provided with every shipment. Our quality management system supports compliance with cGMP and ISO standards for pharmaceutical and industrial use.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) to prevent decomposition. For solutions, store at 2-8°C in a cool, dry, well-ventilated area. Keep away from heat, sparks, open flames, and incompatible materials such as water, acids, and oxidizing agents.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow or brown
Identification (IR)	Conforms
Concentration (in THF)	0.5 M, 1.0 M, or Custom
Assay (Titration)	≥ 95% (of stated concentration)
Residual Magnesium	Contact for details
Solvent (if supplied as solution)	THF, Diethyl ether, or Custom

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.