Description

3,4-(Methylenedioxy)Phenylmagnesium Bromide is a highly reactive Grignard reagent featuring a methylenedioxy-protected catechol moiety. This compound matters as a versatile and critical building block for introducing the 3,4-(methylenedioxy)phenyl group into complex molecular architectures via carbon-carbon bond formation. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for synthesizing active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediates: Key precursor in the synthesis of active pharmaceutical ingredients (APIs) with benzodioxole cores, such as certain vasodilators and CNS-active compounds.
• Agrochemical Synthesis: Used to construct complex molecules for crop protection agents, including fungicides and herbicides.
• Fine Chemical Manufacturing: Employed in the production of specialty chemicals, flavors, and fragrances where the methylenedioxybenzene structure is required.
• Material Science Research: Serves as a monomer or functionalization agent in the development of novel polymers and organic electronic materials.
• Cross-Coupling Reactions: Acts as an organometallic coupling partner in palladium-catalyzed reactions (e.g., Kumada coupling) for biaryl synthesis.
• Nucleophilic Addition: Reacts with a wide range of electrophiles including carbonyl compounds (aldehydes, ketones, esters) and epoxides to form new C-C bonds.

Basic Information

Product Name	3,4-(Methylenedioxy)Phenylmagnesium Bromide
CAS No.	17680-04-5
Molecular Formula	C7H5BrMgO2
Molecular Weight	225.32 g/mol
Synonyms	1,3-Benzodioxol-5-ylmagnesium Bromide; 3,4-Methylenedioxyphenylmagnesium Bromide; 5-Magnesiobromo-1,3-benzodioxole; Piperonylmagnesium Bromide; (1,3-Benzodioxol-5-yl)magnesium Bromide; 5-Bromomagnesio-1,3-benzodioxole; 3,4-(Methylenedioxy)benzenemagnesium Bromide
EINECS	Contact for details

Quality Control

Our 3,4-(Methylenedioxy)Phenylmagnesium Bromide is manufactured under stringent quality systems. Each batch undergoes rigorous analytical testing, including titration for Grignard concentration and GC/HPLC analysis for purity and solvent content, to ensure consistency and reliability for your synthetic workflows. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile, easily oxidized, and hygroscopic. It must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for prolonged stability. Keep the container tightly sealed in a cool, dry, well-ventilated place, away from incompatible materials such as strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Brown to dark brown solution
Concentration (in THF or Ether)	0.5 M - 2.0 M (Customizable)
Assay (by Titration)	≥ 95% (as Grignard Reagent)
Purity (GC/HPLC)	Contact for details
Solvent	Tetrahydrofuran or Diethyl Ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.