Description

2',3'-Dideoxyuridine-5'-Triphosphate (CAS NO 84445-38-5) is a modified nucleoside triphosphate analog critical for advanced molecular biology and biochemical research. Its primary value lies in its role as a chain terminator in nucleic acid sequencing and synthesis, enabling precise genetic analysis. This high-purity biochemical is essential for researchers and manufacturers in the fields of pharmaceutical development, diagnostic assay production, and academic life sciences.

Application

• DNA Sequencing: Used as a chain-terminating substrate in Sanger sequencing and next-generation sequencing (NGS) methodologies.
• Enzymatic Synthesis: Acts as a specialized building block for the enzymatic synthesis of modified oligonucleotides.
• Biochemical Research: Serves as a critical reagent in studies of DNA polymerase kinetics, fidelity, and inhibition mechanisms.
• Antiviral Drug Development: Investigated as a precursor or analog in the research and development of nucleoside-based antiviral therapeutics.
• Diagnostic Kits: Incorporated into molecular diagnostic kits for the detection and analysis of specific genetic sequences.
• Labeling & Detection: Can be used in the preparation of labeled probes for various hybridization and detection applications.

Basic Information

Product Name	2',3'-Dideoxyuridine-5'-Triphosphate
CAS No.	84445-38-5
Molecular Formula	C9H14N2O13P3
Molecular Weight	466.13 g/mol
Synonyms	ddUTP; 2',3'-Dideoxyuridine Triphosphate; 2',3'-ddUTP; Dideoxyuridine-5'-triphosphate; Uridine, 2',3'-dideoxy-, 5'-(tetrahydrogen triphosphate); 5'-Triphosphoric acid, 2',3'-dideoxyuridine; ddUTP sodium salt (common form)
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxyuridine-5'-Triphosphate is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive research applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation. Comprehensive Certificates of Analysis (COA) detailing all specifications are provided to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Anhydrous basis)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, slightly soluble in methanol
Biological Activity	Suitable for enzymatic incorporation

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.