Description

Guanosine 5'-(Tetrahydrogen Triphosphate), 2'-Deoxy-, Tetralithium Salt is a high-purity nucleotide triphosphate analog, specifically the tetralithium salt of 2'-deoxyguanosine-5'-triphosphate (dGTP). This compound is a critical building block for DNA synthesis, serving as a direct substrate for DNA polymerases in enzymatic reactions. It is essential for researchers and manufacturers in molecular biology, diagnostics, and pharmaceutical development, particularly for applications like PCR, DNA sequencing, and cDNA synthesis where precise and reliable nucleotide incorporation is paramount.

Application

• Molecular Biology Research: Essential substrate for PCR (Polymerase Chain Reaction), site-directed mutagenesis, and DNA labeling.
• Next-Generation Sequencing (NGS): Key component in sequencing-by-synthesis platforms for accurate base incorporation.
• Diagnostic Kit Manufacturing: Used in the production of kits for genetic testing, viral load detection, and pathogen identification.
• cDNA Synthesis: Provides the guanine nucleotide for reverse transcription during first-strand cDNA synthesis from RNA templates.
• Enzymatic DNA Synthesis: A fundamental raw material in emerging enzymatic methods for de novo DNA synthesis.
• Biochemical Assays: Used in enzyme kinetics studies of polymerases, helicases, and other nucleic acid-metabolizing enzymes.

Basic Information

Product Name	Guanosine 5'-(Tetrahydrogen Triphosphate), 2'-Deoxy-, Tetralithium Salt
CAS No.	83711-62-0
Molecular Formula	C10H12Li4N5O13P3
Molecular Weight	551.01 g/mol (anhydrous)
Synonyms	2'-Deoxyguanosine-5'-triphosphate tetralithium salt; dGTP, Tetralithium salt; Deoxyguanosine triphosphate lithium salt; 2'-Deoxy-GTP Li4; dGTP-Li4; 5'-dGTP tetralithium; Guanosine, 2'-deoxy-, 5'-(tetrahydrogen triphosphate), tetralithium salt
EINECS	Contact for details

Quality Control

Our nucleotide products are manufactured under strict quality control protocols to ensure the high purity and consistency required for sensitive life science applications. Each batch is tested to confirm identity, potency, and the absence of contaminating nucleases. Certificates of Analysis (COA) detailing purity (by HPLC), pH, and endotoxin levels are available upon request. We support compliance with relevant quality frameworks for diagnostic and research use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95%
Assay (Enzymatic)	≥ 90%
pH (1% Solution)	6.5 - 7.5
Moisture Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.