Description

1-(N(3)-Deoxycytidyl)-2-(N(1)-Deoxyguanosinyl)Ethane is a defined, high-purity cross-linked dinucleotide derivative, serving as a critical reference standard and research reagent. This compound is essential for studying DNA damage, cross-linking mechanisms, and the structural and functional consequences of interstrand adducts in nucleic acids. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic developers focused on oncology, mutagenesis, and advanced molecular biology applications.

Application

• Biochemical Research Standard: Used as a certified reference material for quantifying and characterizing DNA interstrand cross-links (ICLs) in experimental models.
• Oncology & Cancer Research: Critical for investigating the mechanisms of action of bifunctional alkylating chemotherapeutic agents and understanding drug-induced DNA damage.
• Genotoxicity & Mutagenesis Studies: Employed as a specific substrate or adduct standard in assays designed to evaluate the genotoxic potential of chemicals and environmental toxins.
• DNA Repair Pathway Analysis: Serves as a defined lesion to study the efficiency and mechanisms of cellular DNA repair pathways, such as nucleotide excision repair (NER) and Fanconi anemia (FA) pathways.
• Diagnostic Assay Development: Used in the development and calibration of sensitive analytical methods (e.g., LC-MS/MS, ELISA) for detecting specific DNA adducts as biomarkers of exposure or effect.
• Structural Biology Studies: Provides a well-defined lesion for NMR and X-ray crystallography studies to elucidate the structural distortions caused by specific cross-links in DNA duplexes.

Basic Information

Product Name	1-(N(3)-Deoxycytidyl)-2-(N(1)-Deoxyguanosinyl)Ethane
CAS No.	83008-59-7
Molecular Formula	C21H28N8O10P2
Molecular Weight	626.44 g/mol
Synonyms	1,N2-Etheno-2'-deoxyguanosine-3',5'-bisphosphate; dG-dC Ethano Adduct; 1-(3-(2-Deoxy-β-D-erythro-pentofuranosyl)-2,4(1H,3H)-pyrimidinedion-5-yl)-2-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)ethane; DNA Interstrand Cross-Link Model Compound; G-C Etheno Crosslink; d(CpG) Etheno Adduct; 1,N2-Ethenoguanine-cytosine Crosslink
EINECS	Contact for details

Quality Control

Every batch of 1-(N(3)-Deoxycytidyl)-2-(N(1)-Deoxyguanosinyl)Ethane is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency for research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting standards for reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with molecular structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by UV spectrophotometry)
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.