Description

Poly(Deoxyguanylic Acid-5-Bromo-Deoxycytidylic Acid) is a synthetic, sequence-defined oligonucleotide polymer incorporating a brominated cytidine analog. This modified nucleic acid is a critical research tool for studying DNA structure, stability, and interactions, particularly in contexts involving halogen bonding and mutagenesis. It is primarily utilized by biopharmaceutical R&D teams, academic research institutions, and diagnostic developers focused on nucleic acid chemistry and molecular biology applications.

Application

• Biochemical Research: Used as a model compound to investigate the effects of halogenated nucleobases on DNA duplex stability, conformation, and protein-binding affinity.
• Probe Development: Serves as a component in the design of specialized hybridization probes and primers for diagnostic assays targeting specific genetic sequences.
• Structural Studies: Employed in X-ray crystallography and NMR spectroscopy to elucidate the three-dimensional structure of DNA containing modified bases.
• Mechanistic Studies: Aids in research on DNA damage, repair mechanisms, and the biochemical pathways involving halogenated nucleotides.
• Pharmaceutical R&D: Potential use in the early-stage development of antisense oligonucleotides, aptamers, and other therapeutic nucleic acid platforms.

Basic Information

Product Name	Poly(Deoxyguanylic Acid-5-Bromo-Deoxycytidylic Acid)
CAS No.	82996-76-7
Molecular Formula	(C19H22BrN7O11P2)n
Molecular Weight	Contact for details
Synonyms	Poly(dG-dC-br5); Poly(dG-dBr5C); Poly(deoxyguanylyl-deoxy-5-bromocytidylyl); 5-Bromo-2'-deoxycytidylic acid polymer with 2'-deoxyguanylic acid; Brominated poly(dG-dC); Poly(dG-dC) brominated; Alternating dG-dBrC polymer; Synthetic brominated DNA polymer
EINECS	Contact for details

Quality Control

Our Poly(Deoxyguanylic Acid-5-Bromo-Deoxycytidylic Acid) is manufactured under controlled conditions to ensure batch-to-batch consistency for research applications. Quality is verified through a suite of analytical techniques including HPLC for purity, UV-Vis spectroscopy for concentration and integrity, and gel electrophoresis for chain length assessment. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and physical state is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a non-frost-free freezer for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For extended storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (UV-Vis)	Conforms
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 95%
Base Composition	1:1 ratio (dG:dBrC)
Extinction Coefficient	Provided on COA
Chain Length (Average)	Contact for details
Solubility	Soluble in TE buffer, water
Moisture Content (KF)	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.