Description

Poly(7-Deazaguanylic Acid) CAS NO 82513-50-6 is a synthetic oligonucleotide analog, specifically a polymer of 7-deazaguanosine monophosphate, designed for advanced biochemical and pharmaceutical research. This compound is valued for its unique nucleobase modification, which enhances stability against enzymatic degradation and alters base-pairing properties, making it a critical tool for studying nucleic acid structure and function. It is primarily utilized by research institutions and biotechnology companies engaged in antisense technology, diagnostic probe development, and fundamental studies of nucleic acid interactions.

Application

• Antisense Oligonucleotide Research: Serves as a stable backbone component for developing novel antisense agents targeting gene expression.
• Diagnostic Probe Synthesis: Used in the creation of specialized probes for fluorescence in situ hybridization (FISH) and other molecular diagnostic assays due to its altered hybridization characteristics.
• Nucleic Acid Structure-Function Studies: A vital reagent for investigating the role of hydrogen bonding and base stacking in DNA/RNA duplex stability and conformation.
• Aptamer Development: Employed in SELEX (Systematic Evolution of Ligands by Exponential Enrichment) processes to generate nuclease-resistant aptamers with high binding affinity.
• Therapeutic Nucleic Acid Research: Explored as a building block for next-generation therapeutic oligonucleotides, including siRNA and miRNA mimics, where enhanced metabolic stability is required.
• Biochemical Tool Development: Integrated into custom primers and templates for specialized PCR applications and enzymatic studies.

Basic Information

Product Name	Poly(7-Deazaguanylic Acid)
CAS No.	82513-50-6
Molecular Formula	(C10H12N4O7P)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(7-deazaguanylate); Poly(7-deaza-GMP); Poly(c7-GMP); Poly(7-carbaguanosine phosphate); 7-Deazaguanosine homopolymer; Poly(7-cyano-7-deazaguanosine phosphate); Poly(7-CN-7-carba-GMP); PPG (Poly-Purine Guanine analog)
EINECS	Contact for details

Quality Control

Every batch of Poly(7-Deazaguanylic Acid) is manufactured and tested under stringent quality management protocols to ensure consistency and purity for critical research applications. Our products undergo rigorous quality testing, including chromatographic and spectroscopic analysis, to ensure compliance with exacting research-grade standards. Certificates of Analysis (COA) detailing purity, molecular weight distribution, and endotoxin levels are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or light may lead to degradation. For long-term storage, keep desiccated under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Average Chain Length (n)	10 - 30 (Custom lengths available)
Endotoxin Level	< 10 EU/mg
Solubility	Soluble in aqueous buffers, DMSO
Moisture Content (KF)	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.