Description

4-Fluoro-3-Methylphenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic syntheses. Its value lies in its ability to introduce the versatile 4-fluoro-3-methylphenyl moiety into target molecules, enabling the creation of advanced intermediates for pharmaceuticals and agrochemicals. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for constructing active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Development: Used in the synthesis of advanced herbicides, fungicides, and insecticides where the fluorine-substituted aromatic ring imparts specific biological activity and environmental persistence profiles.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers where precise fluorination patterns are critical for performance.
• Cross-Coupling Reactions: Serves as a nucleophile in palladium-catalyzed cross-coupling reactions (e.g., Kumada coupling) to form biaryl structures.
• Nucleophilic Addition to Carbonyls: Reacts with aldehydes, ketones, esters, and carbon dioxide to produce secondary/tertiary alcohols and carboxylic acid derivatives.
• Custom Chemical Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring fluorinated aromatic units.

Basic Information

Product Name	4-Fluoro-3-Methylphenylmagnesium Bromide
CAS No.	82297-89-0
Molecular Formula	C7H6FMgBr
Molecular Weight	213.33 g/mol
Synonyms	(4-Fluoro-3-methylphenyl)magnesium bromide; 3-Methyl-4-fluorophenylmagnesium bromide; 4-Fluoro-m-tolylmagnesium bromide; Magnesium, bromo(4-fluoro-3-methylphenyl)-; Grignard Reagent (4-Fluoro-3-methylphenyl); 1-Fluoro-2-methyl-4-(bromomagnesio)benzene; 4-Fluoro-3-methyl-1-bromomagnesio-benzene
EINECS	Contact for details

Quality Control

Every batch of our 4-Fluoro-3-Methylphenylmagnesium Bromide undergoes rigorous quality testing to ensure consistency, reactivity, and purity for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as concentration, titration assay, and impurity profile. Our quality management system is designed to meet the stringent standards required for pharmaceutical and advanced chemical research, ensuring reliable and reproducible performance in your critical reactions.

Storage

Preserve in a tightly closed container, protected from light. This reagent is typically supplied and stored as a solution in diethyl ether or tetrahydrofuran under an inert atmosphere (argon or nitrogen) to prevent degradation. Store in a cool, dry, well-ventilated area, away from heat, sparks, and open flames. Due to its highly volatile and pyrophoric nature, it must be handled exclusively under inert conditions. Recommended storage temperature is 2-8°C for extended stability, though specific conditions depend on the solvent and concentration.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light brown
Concentration	0.5 M to 2.0 M in specified solvent (Typical: 1.0 M in THF or Diethyl Ether)
Assay (Titration)	≥ 95%
Identification (IR)	Conforms to structure
Solvent	Anhydrous Tetrahydrofuran or Diethyl Ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.