Description

Bu-Dmt-Deoxyguanosine 2-Clph Diester Barium is a specialized, high-purity chemical intermediate used in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring precise building blocks for oligonucleotide and nucleoside analog development. It is primarily utilized by the pharmaceutical, biotechnology, and life science research sectors for applications in drug discovery and nucleic acid chemistry.

Application

• Oligonucleotide Synthesis: Acts as a key phosphoramidite precursor or protected monomer in solid-phase synthesis for research and therapeutic oligonucleotides.
• Antiviral & Anticancer Prodrug Development: Serves as a protected nucleoside intermediate in the synthesis of nucleoside analogs with potential therapeutic activity.
• Bioconjugation & Labeling: Used to introduce modified deoxyguanosine bases into biomolecules for diagnostic probes or targeted delivery systems.
• Chemical Biology Research: A valuable tool for studying DNA/RNA interactions, enzyme mechanisms, and as a scaffold for library synthesis in medicinal chemistry.
• Process Development & Scale-up: Employed in the pilot and commercial-scale manufacturing of active pharmaceutical ingredients (APIs) based on nucleoside chemistry.

Basic Information

Product Name	Bu-Dmt-Deoxyguanosine 2-Clph Diester Barium
CAS No.	82224-97-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Barium Bu-DMT-deoxyguanosine 2-chlorophenyl diester; 2'-Deoxyguanosine, 5'-(bis(4-chlorophenyl) hydrogen phosphate), 3'-(4,4'-dimethoxytrityl)-, barium salt; Barium 5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine 3'-(bis(4-chlorophenyl) phosphate); DMT-dG(2-ClPh) Barium Salt; Protected deoxyguanosine phosphotriester barium salt; Nucleoside phosphotriester intermediate; Barium 2-chlorophenyl DMT-deoxyguanosine diester
EINECS	Contact for details

Quality Control

Our Bu-Dmt-Deoxyguanosine 2-Clph Diester Barium is manufactured under strict quality systems to ensure batch-to-batch consistency for critical research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and related substances is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.