Description

2-Biphenylylmagnesium Bromide 0.5M in THF is a versatile organometallic reagent, specifically a Grignard reagent, widely used in synthetic organic chemistry for the formation of carbon-carbon bonds. Its primary value lies in enabling the efficient and selective introduction of the 2-biphenylyl moiety into complex molecular architectures, a critical step in the synthesis of advanced intermediates. This high-purity solution is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, facilitating the development of active ingredients, functional materials, and novel chemical entities.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing biphenyl-containing scaffolds found in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of herbicides, fungicides, and insecticides where the biphenyl structure imparts specific biological activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized phosphine or N-heterocyclic carbene (NHC) ligands used in transition metal catalysis.
• Materials Science Research: Employed in the creation of organic electronic materials, such as those for OLEDs (Organic Light-Emitting Diodes) and semiconductors, where conjugated biphenyl systems are valuable.
• Fine Chemical Production: Facilitates the synthesis of complex, high-value specialty chemicals and flavors & fragrances.
• Cross-Coupling Reactions: Acts as a nucleophilic coupling partner in palladium-catalyzed reactions like Kumada, Negishi, or Suzuki-Miyaura cross-couplings.

Basic Information

Product Name	2-Biphenylylmagnesium Bromide 0.5M in THF
CAS No.	82214-69-5
Molecular Formula	C12H9BrMg
Molecular Weight	257.41 g/mol
Synonyms	2-Biphenylylmagnesium Bromide; (1,1'-Biphenyl]-2-ylmagnesium Bromide; 2-Phenylphenylmagnesium Bromide; o-Phenylphenylmagnesium Bromide; Biphenyl-2-ylmagnesium Bromide; Grignard Reagent (2-Biphenylyl); [1,1'-Biphenyl]-2-ylmagnesium Bromide Solution; 2-Biphenylmagnesium Bromide
EINECS	Contact for details

Quality Control

Every batch of our 2-Biphenylylmagnesium Bromide 0.5M solution is manufactured and tested under stringent quality management systems. We ensure consistent concentration, purity, and reactivity through advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing assay, titration results, and solvent purity is provided with each shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C (refrigerated) to maintain stability and prevent degradation. The solution is highly volatile, moisture-sensitive, and easily oxidized; therefore, it must be handled in a dry, inert environment using standard Schlenk or glovebox techniques.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration	0.5 M in Tetrahydrofuran (THF)
Assay (Titration)	≥ 0.5 M
Solvent (THF) Purity	≥ 99.9%
Water Content (Karl Fischer)	≤ 50 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.