Description

Trioxacarcin is a potent, naturally occurring antibiotic compound belonging to the family of benz[a]anthraquinone antitumor agents. This molecule is of significant interest in pharmaceutical research due to its unique mechanism of action, which involves DNA alkylation and cross-linking, leading to potent cytotoxic effects. It serves as a critical reference standard and a promising scaffold for researchers in oncology and medicinal chemistry, particularly for the development of novel anticancer therapeutics and the study of DNA-damaging agents.

Application

• Pharmaceutical Research & Development: As a high-purity reference standard for analytical method development, validation, and quality control in drug discovery pipelines.
• Anticancer Agent Studies: Used as a biochemical tool to investigate mechanisms of DNA damage, cell cycle arrest, and apoptosis in various cancer cell lines.
• Medicinal Chemistry: Serves as a lead compound or a core structure for the synthesis and evaluation of novel analogs with improved efficacy and reduced toxicity.
• Academic Research: Employed in university and institutional labs for fundamental studies in microbiology, molecular biology, and chemical biology related to antibiotic action and resistance.
• Biochemical Assays: Utilized as a precise reagent in in vitro assays to screen for DNA repair inhibitors or to study the specificity of DNA-binding proteins.

Basic Information

Product Name	Trioxacarcin
CAS No.	81831-80-3
Molecular Formula	C₃₉H₄₀O₁₄
Molecular Weight	732.73 g/mol
Synonyms	Trioxacarcin A; LL-D49194; U-62162; NSC 347155; Benz[a]anthracene-7,14-dione, 1,2,3,4,4a,12b-hexah-8,9,10-trihydroxy-6-methoxy-1,2,12b-trimethyl-; Antibiotic LL-D49194; Antibiotic U-62162
EINECS	Contact for details

Quality Control

Every batch of Trioxacarcin is manufactured and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay results, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.