Description

1,N(6)-Etheno-2'-Deoxyadenosine 5'-Triphosphate is a chemically modified nucleotide analog, specifically an etheno-derivatized deoxyadenosine triphosphate. This modification is critical for its role as a potent fluorescent probe and a substrate analog in advanced biochemical research. It is primarily required by research institutions and diagnostic developers working in molecular biology, enzymology, and nucleic acid chemistry. The compound is valued for its unique properties in studying DNA adduct formation, polymerase activity, and developing sensitive detection assays.

Application

• Biochemical Research Probe: Used as a fluorescent substrate to study the kinetics and mechanisms of DNA polymerases and other nucleotide-processing enzymes.
• DNA Adduct Studies: Serves as a model compound for investigating the formation, detection, and repair of etheno-DNA adducts, which are biomarkers of oxidative stress and exposure to certain carcinogens.
• Enzyme Inhibition Assays: Acts as a competitive inhibitor or alternative substrate in high-throughput screening assays for drug discovery targeting nucleotide metabolism.
• Diagnostic Development: Employed in the development of sensitive diagnostic kits and assays for detecting specific enzymatic activities or DNA damage.
• Structural Biology: Used in X-ray crystallography and NMR studies to elucidate the three-dimensional structure of enzyme-substrate complexes.
• Nucleic Acid Labeling: Can be utilized for the site-specific fluorescent labeling of DNA strands in probe development.

Basic Information

Product Name	1,N(6)-Etheno-2'-Deoxyadenosine 5'-Triphosphate
CAS No.	81004-54-8
Molecular Formula	C₁₅H₂₁N₅O₁₂P₃
Molecular Weight	604.29 g/mol
Synonyms	1,N6-Etheno-2'-deoxyadenosine-5'-triphosphate; ε-dATP; Etheno-dATP; 1,N6-Etheno-2'-deoxyadenosine triphosphate; 2'-Deoxy-1,N6-ethenoadenosine 5'-triphosphate; ε-2'-Deoxyadenosine triphosphate; 1,N6-ε-dATP; 1,N6-Etheno-dATP
EINECS	Contact for details

Quality Control

Our 1,N(6)-Etheno-2'-Deoxyadenosine 5'-Triphosphate is produced under stringent quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material tailored to specific research-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under inert atmosphere or vacuum desiccation to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.